Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Antidepressants Modulate Behavioral, Biochemical, and Histological Alterations Induced by Chronic Aluminum Chloride Administration in Wistar Rats

    Arshad Basha Shaik1, Smita Shenoy1★, V. Anupama2, K. G. Mohandas Rao3, Arul Amuthan4★ Corresponding author

    1. 1Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
    2. 2Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
    3. 3Department of Anatomy, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
    4. 4Department of Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

    CORRESPONDENCE

    Smita Shenoy

    Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576 104, Karnataka, India.

    smita.shenoy@manipal.edu

    Received: 08-12-2018; Revised: 15-02-2019; Accepted: 01-04-2019.

    Volume 10, Issue 1 · pp. 16–21 · PUBLISHED 2019 · DOI: 10.4103/jpp.JPP_135_18

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To assess the effect of duloxetine and escitalopram on aluminum chloride (AlCl3)-induced memory impairment in rats. Materials and Methods: Thirty rats were used. Group-I (control) and Group-II (toxic control) received 2% gum acacia, 10 mL/kg and AlCl3, 175 mg/kg, respectively. Group-III (standard), Group-IV, and Group-V (test drug groups) received rivastigmine (1 mg/kg), duloxetine (10 mg/kg), and escitalopram (10 mg/kg), respectively, along with AlCl3, 175 mg/kg. All drugs and AlCl3 were administered orally daily for 2 months. The effect on cognition was assessed by Morris water maze (MWM). Brain acetylcholinesterase levels, oxidative stress parameters, and histology of the hippocampus were also evaluated. Results: Rats treated with only AlCl3 showed significant (P < 0.001) increase in latency during acquisition trials of day-3 and day-4 and decrease in percentage of both time spent and distance traveled in target zone during probe trial in MWM. Malondialdehyde was increased and glutathione decreased in the brain. Histopathology of the hippocampus showed unhealthy cellular architecture with a large number of degenerated cells. All these changes were significantly reversed in rivastigmine and test drug groups. Chronic administration of AlCl3 resulted in lowering of brain cholinesterase levels (P < 0.001) versus control. Cholinesterase levels were further significantly (P < 0.05) lowered in rats who received AlCl3 along with either rivastigmine or escitalopram. Conclusion: Escitalopram and duloxetine exerted a protective effect against AlCl3-induced memory impairment in rats.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Shaik, A. B., Shenoy, S., Anupama, V., Rao, K. G. M., & Amuthan, A. (2019). Antidepressants Modulate Behavioral, Biochemical, and Histological Alterations Induced by Chronic Aluminum Chloride Administration in Wistar Rats. Journal of Pharmacology and Pharmacotherapeutics, 10(1), 16–21. https://doi.org/10.4103/jpp.JPP_135_18