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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Review

    A Deep Insight into the Correlation Between Gut Dysbiosis and Alzheimer’s Amyloidopathy

    Sreenivasulu Naidu Kondaveeti1, Dithu Thekkekkara1★, Lakshmi T Narayanan1, S. N. Manjula1, Y Mohammed Tausif1, Amrita Babu1, SK Meheronnisha1★ Corresponding author

    1. 1Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, India.

    CORRESPONDENCE

    Dithu Thekkekkara

    Department of Pharmacology, JSS College of Pharmacy, JSSAHER, SS Nagar, Mysuru 570015, Karnataka, India.

    dithuthekkekkara@jssuni.edu.in

    ORCID: 0000-0002-8341-4895

    Received: 14-09-2022; Revised: 22-10-2022; Accepted: 21-11-2022.

    Volume 13, Issue 4 · pp. 305–315 · PUBLISHED 2022 · DOI: 10.1177/0976500X221150310

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Recent research has shown a strong correlation between gut dysbiosis and Alzheimer’s disease (AD). The purpose of this review is to investigate the relationship between gut dysbiosis, immune system activation, and the onset of AD and to examine current breakthroughs in microbiota-targeted AD therapeutics. A review of scientific literature was conducted to assess the correlation between gut dysbiosis and AD and the various factors associated. Gut dysbiosis produces an increase in harmful substances, such as bacterial amyloids, which makes the gut barrier and blood-brain barrier more permeable. This leads to the stimulation of immunological responses and an increase in cytokines such as interleukin-1β (IL-1β). As a result, gut dysbiosis accelerates the progression of AD. The review highlights the connection between gut dysbiosis and AD and the potential for microbiota-targeted therapies in AD treatment.

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      Kondaveeti, S. N., Thekkekkara, D., Narayanan, L. T., Manjula, S. N., Tausif, Y. M., Babu, A., & Meheronnisha, S. (2022). A Deep Insight into the Correlation Between Gut Dysbiosis and Alzheimer’s Amyloidopathy. Journal of Pharmacology and Pharmacotherapeutics, 13(4), 305–315. https://doi.org/10.1177/0976500X221150310