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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Quercetin Exerts a Protective Effect on Ischemic Stroke-induced Memory Deficits in Mice

    Chrismawan Ardianto1,2★, Dewi Lestari1, Luthfia Hany Primadani1, Dwi Retno Puspitasari1, I Nengah Budi Sumartha1, Khoirotin Nisak1, Aniek Setiya Budiatin1, Dewi Wara Shinta1, Mareta Rindang Andarsari1, Farida Ifadotunnikmah3, Amar Daud Iskandar Abdullah4, Mahardian Rahmadi1,2, Junaidi Khotib1★ Corresponding author

    1. 1Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
    2. 2Biomedical Pharmacy Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
    3. 3Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
    4. 4Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.

    CORRESPONDENCE

    Chrismawan Ardianto

    Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java 60115, Indonesia.

    chrismawan-a@ff.unair.ac.id

    Received: 02-04-2023; Revised: 05-06-2023; Accepted: 07-06-2023.

    Volume 14, Issue 2 · pp. 133–141 · PUBLISHED 2023 · DOI: 10.1177/0976500X231189343

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objectives: Brain injury resulting from an ischemic stroke affects cognitive performance by disrupting the hippocampus. Several processes are involved in brain injury progression, including inflammation, glutamate excitotoxicity, and modulated brain peptide systems such as the melanocortin system. Reports show that quercetin exerts neuroprotective activity. This study investigates quercetin’s role in the cognitive function of ischemic stroke-induced mice and the possible mechanisms involved. Materials and Methods: ICR mice were used. The left unilateral common carotid artery occlusion was conducted for 4 h to induce an ischemic stroke in the mice. Quercetin 50, 100, and 200 mg/kg were administered to separate groups intraperitoneally for 7 days. Cognitive function was examined using the T-maze test. The hippocampal mRNA expressions of NR2A, NR2B, melanocortin 4 receptor (MC4R), pro-opiomelanocortin precursors (POMC), and nuclear factor 2 (Nrf2) were examined using reverse transcription-polymerase chain reaction. Results: It was found that stroke disrupted cognitive function. Quercetin administration ameliorated cognitive impairment. Quercetin attenuated the stroke-induced decrease in MC4R mRNA expression. Moreover, quercetin suppressed the stroke-induced increase in the hippocampal mRNA expression of NR2A. Conclusion: Quercetin ameliorates cognitive deficits and normalizes impaired hippocampal melanocortin and glutamatergic signaling in ischemic stroke-induced mice.

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      Ardianto, C., Lestari, D., Primadani, L. H., Puspitasari, D. R., Sumartha, I. N. B., Nisak, K., Budiatin, A. S., Shinta, D. W., Andarsari, M. R., Ifadotunnikmah, F., Abdullah, A. D. I., Rahmadi, M., & Khotib, J. (2023). Quercetin Exerts a Protective Effect on Ischemic Stroke-induced Memory Deficits in Mice. Journal of Pharmacology and Pharmacotherapeutics, 14(2), 133–141. https://doi.org/10.1177/0976500X231189343