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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Review

    Rationalization of Antibiotic Prescription: Modulation of the Gut Microbiome and Possibilities of Minimizing the Risks for the Development of Antibiotic Resistance—A Narrative Review

    Ashok Kumar1, Aman Shukla1★, Pottathil Shinu2, Bijo Mathew3, Shashank Kailkhura1, Pranjal Pratap Singh4, Anroop B. Nair5★ Corresponding author

    1. 1School of Pharmacy, Graphic Era Hill University, Society Area, Clement Town, Dehradun, Uttarakhand, India.
    2. 2Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
    3. 3Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeeth, Kochi, Kerala, India.
    4. 4GRD Institute of Management & Technology, Dehradun, Uttarakhand, India.
    5. 5Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

    CORRESPONDENCE

    Aman Shukla

    School of Pharmacy, Graphic Era Hill University, Society Area, Clement Town, Dehradun, Uttarakhand 248002, India.

    amanlesnar12@gmail.com

    Received: 09-05-2023; Revised: 24-06-2023; Accepted: 26-06-2023.

    Volume 14, Issue 2 · pp. 93–106 · PUBLISHED 2023 · DOI: 10.1177/0976500X231189341

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Antimicrobial resistance (AMR) is a serious global health issue, and it is greatly influenced by the gut flora. The rationalization of antimicrobial doses in clinical studies is crucial for preventing AMR. This review analyzes how rationalization tactics affect AMR and gut microbiota in clinical studies. Studies that provided data on the use of antibiotics, AMR, or gastrointestinal microbiota were taken into account for the current review. The AMR rate was found to be low when healthy gut flora was maintained using various antibiotic rationalization techniques, such as limited use of antibiotics or targeted treatments. However, the effectiveness of these strategies differed based on the particular intervention, the research population, and the length of the course of therapy. The rationalization of antibiotic prescriptions in clinical research is one potential method for reducing the prevalence of AMR by maintaining the gut flora. Rationalization techniques may help lower AMR rates and foster the development of good intestinal flora. This review describes various antibiotic rationalization techniques and the importance of maintaining healthy microbial flora to minimize AMR-associated health issues.

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      Kumar, A., Shukla, A., Shinu, P., Mathew, B., Kailkhura, S., Singh, P. P., & Nair, A. B. (2023). Rationalization of Antibiotic Prescription: Modulation of the Gut Microbiome and Possibilities of Minimizing the Risks for the Development of Antibiotic Resistance—A Narrative Review. Journal of Pharmacology and Pharmacotherapeutics, 14(2), 93–106. https://doi.org/10.1177/0976500X231189341