Phytochemical Characterization and Anticancer Screening of Cladophora goensis and Cladophora glomerata Extracts

ABSTRACT

Background: Cladophora goensis and Cladophora glomerata has been widely identified in the Indian Oceans. Marine algae have been identified as potential pharmacological agents useful in the treatment of diabetes, hypertension, infections, and cancers. Objectives: The present study aimed to evaluate the phytochemicals in C. goensis and C. glomerata using gas chromatography-mass spectroscopy (GC-MS), and to study the molecular interactions with cancer-related proteins using molecular docking techniques. Materials and methods: GC-MS analysis was done using electron impact ionization at 70eV and the data was evaluated using total ion count for compound identification and quantification. AutoDock 4.0 version was used for the molecular docking analysis. Results: The methanolic extracts of algae when subjected to GC-MS analysis, 19 compounds from C. goensis and 11 phytocompounds from C. glomerata were identified. The significant molecular interactions of phytochemicals of C. goensis (6-nitro-3H-quinazolin-4-one, Isoquinoline, 1,2,3,4-tetrahydro-7-methoxy-2-methyl-8-(phenyl methoxy) and 9-Decen-1-ol, pentafluropropionate) and C. glomerata (phytol, palmitic acid, and octadec-9-enoic acid) against human epidermal growth factor receptor (4WRG), poly (ADP-ribose) polymerase-1 (4UND), human estrogen receptor alpha ligand-binding domain (3ERT), human peroxisome proliferator-activated receptor alpha ligand-binding domain (3VI8), and human topoisomerase (1EJ9) have been demonstrated. Conclusion: The phytochemicals of methanolic extracts of C. goensis and C. glomerata showed potential interactions with cancer-related proteins.

KEYWORDS

• Marine biology
• pharmacology
• bioinformatics
• cancer biology
• molecular biology

Showing references and in-text citations exactly as published.

Cite this article

• DOI10.1177/0976500X241235721Copy

RELATED ARTICLES

Matched on section and article type within this issue of J Pharmacol. Pharmacother..

• Article · VOLUME 15, ISSUE 1A Comparative Evaluation of Antimicrobial Efficacy of Various Intracanal Medicaments (Curcuma longa, Honey, Nitrofurantoin, and Calcium Hydroxide) on Enterococcus faecalis: An in vitro StudyM. S. Rangareddy, Shanti Priya P., Basa Srinivas Karteek, Chigurupati Swetha, B. Sravan Kumar, Sumaiya Waheed, Jagrati Agrawal · pp. 19–27Research ArticleSame type: Article
• Article · VOLUME 15, ISSUE 1Competitive Analysis of the Binding Affinity of Montelukast, Zafirlukast and Gemilukast to CysLTR1, P2Y12 and PPAR-γ and their Possible Cardioprotective Effect: Using in silico MethodsMatrika Saha Roy, Bidduth Kumar Sarkar, Md Rohan Nadvi, Arghya Prosun Sarkar, Sukalyan Kumar Kundu, Hossain Ahmed, Md Jahirul Islam, Barno Kumar Sarkar, Peter Singh, Tanushree Maitra, Maruf Hasan · pp. 28–37Research ArticleSame type: Article
• Article · VOLUME 15, ISSUE 1Knowledge and Attitude Towards Traditional, Complementary and Alternative Medicine on Colorectal Cancer Among Northern MalaysiansSubramani Parasuraman, Sam Aaseer Thamby, Ruksana Binti Ashruf, Tan Boon Seng, Nahlah Elkudssiah Ismail · pp. 38–45Research ArticleSame type: Article
• Article · VOLUME 15, ISSUE 1Measurement of Nuchal Translucency Thickness in First Trimester Ultrasound Foetal Images Using Markov Random FieldKalyani Chaudhari, Shruti Oza · pp. 46–53Research ArticleSame type: Article