Exploring the Novel Therapeutic Potential of N-acetylcysteine in Depression, Bipolar Disorders and Anxiety
Reuben P. Syiem1★, Julie B. Wahlang1, Krishnamoorthi R.1, Pavan B. Kalyan1, Diana Nahakpam1, Arky Jane Langstieh1★ Corresponding author
- 1Department of Pharmacology, NEIGRIHMS, Shillong, Meghalaya, India.
CORRESPONDENCE
Reuben P. Syiem
Department of Pharmacology, NEIGRIHMS, Shillong, Meghalaya, India
Received: 04-02-2024; Revised: 25-02-2024; Accepted: 12-03-2024.
Volume 15, Issue 2 · pp. 133–141 · PUBLISHED 2024 · DOI: 10.1177/0976500X241246402
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ABSTRACT
Background: Anxiety disorders, bipolar disorder, and depression are prevalent mental health issues that have a substantial impact on both individuals and the community. Many people continue to have symptoms and do not get the right kind of relief from their existing drugs, even after trying conventional therapy methods. Therefore, to enhance the current treatment modalities and patient results, new therapeutic alternatives are required. In recent years, there has been an increase in interest in N-acetylcysteine (NAC) because of its many biological benefits, including its ability to modulate glutamate levels and its antioxidant and anti-inflammatory properties. According to studies, NAC has encouraging anti-depressant properties and may help treat bipolar disease by stabilizing mood and reducing the risk of relapses. Furthermore, through lowering oxidative stress and modifying neurotransmitter networks, NAC has been shown to lessen the symptoms of anxiety. The preclinical and clinical research examining the efficacy of NAC in depression, bipolar disorders, and anxiety are thoroughly analyzed in this review. Methodology: Books were reviewed and medical and scientific literature found in MEDLINE and PubMed were analyzed for an assessment of NAC’s therapeutic potential in psychiatric illnesses such as anxiety, depression, and bipolar disorder. Conclusion: NAC exhibits potential as a therapeutic agent for psychiatric problems such as anxiety, bipolar disorder, and depression. Performing a thorough clinical study will facilitate proper understanding its efficacy, safety and mechanisms of action.
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Syiem, R. P., Wahlang, J. B., R., K., Kalyan, P. B., Nahakpam, D., & Langstieh, A. J. (2024). Exploring the Novel Therapeutic Potential of N-acetylcysteine in Depression, Bipolar Disorders and Anxiety. Journal of Pharmacology and Pharmacotherapeutics, 15(2), 133–141. https://doi.org/10.1177/0976500X241246402