Adverse drug reactions in inpatients of internal medicine wards at a tertiary care hospital: A prospective cohort study

ABSTRACT

Objective: To find out incidence of adverse drug reactions (ADR) in patients of internal medicine wards and study various aspects of ADR, e.g., causality, mortality, drugs commonly causing ADR in internal medicine wards of Guru Gobind Singh Hospital, Jamnagar, a tertiary care hospital. Materials and Methods: This was prospective, observational study carried out at Department of Medicine, Shri Meghji Pethraj Shah Medical College attached with Guru Gobind Singh Hospital, a tertiary care teaching hospital, Jamnagar, Gujarat over a period of 6 months. For statistical analysis, ADR were analyzed by using Chi-square test. Results: Out of total 860 patients admitted, 830 were analyzed as they met the inclusion criteria. A total of 45 (5.42%) patients developed 47 ADR. Among them, 27 (3.25 %) (95% CI, 2.03%-, 4.47%) patients due to ADR required hospital admission in medicine ward (ADR Ad), 18 (2.17%) (95% CI, 1.17%–3.17%) patients developed ADR while already hospitalized in medicine ward (ADR In). Most of the fatal and life-threatening reactions occurred due to chemotherapeutic agents. Majority of patients discontinued suspected drug and recovered from ADR. Conclusion: Fatal and life-threatening adverse reactions reported in the present as well as other studies underline the importance of such studies and need for creating awareness among health professionals about looking for and reporting such reactions.

KEYWORDS

• Adverse drug reaction
• adverse drug reactions
• cohort study

Showing references and in-text citations exactly as published.

Cite this article

• DOI10.4103/0976-500X.77102Copy

RELATED ARTICLES

Matched on section and article type within this issue of J Pharmacol. Pharmacother..

• Article · VOLUME 2, ISSUE 1Effects of fluoxetine and escitalopram on C-reactive protein in patients of depressionNilesh Chavda, N. D. Kantharia, Jaykaran Jaykaran · pp. 11–12Original PaperSame type: Article
• Article · VOLUME 2, ISSUE 1The incidence and nature of drug-related hospital admission: A 6-month observational study in a tertiary health care hospitalHarminder Singh, Bithika Nel Kumar, Tiku Sinha, Navin Dulhani · pp. 17–18Original PaperSame type: Article
• Article · VOLUME 2, ISSUE 1Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patientsAlpa Pragnesh Gor, Miti Saksena · pp. 26–27Original PaperSame type: Article
• Article · VOLUME 2, ISSUE 1Evaluation of nootropic and neuroprotective effects of low dose aspirin in ratsArijit Ghosh, V. R. Dhumal, A. V. Tilak, Nina Das, Amarinder Singh, Abhijit A. Bondekar · pp. 3–4Original PaperSame type: Article