Rabeprazole and esomeprazole in mild-to-moderate erosive gastroesophageal reflux disease: A comparative study of efficacy and safety
Rituparna Maiti1★, Jyothirmai Jaida1, P. L. John Israel2, Narendar Koyagura1, Sruthi Mukkisa1★ Corresponding author
- 1Anuradha Palani Departments of Pharmacology.
- 2General Medicine, Prathima Institute of Medical Sciences, Nagunur Road, Karimnagar, Andhra Pradesh, India Research Paper.
CORRESPONDENCE
Rituparna Maiti
Anuradha Palani Departments of Pharmacology.
Volume 2, Issue 3 · pp. 150–157 · PUBLISHED 2011 · DOI: 10.4103/0976-500X.83278
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ABSTRACT
Objective: To compare the effi cacy and safety of rabeprazole and esomeprazole in mild-to-moderate erosive gastroesophageal refl ux disease (GERD). Materials and Methods: A randomized, single-blinded, outdoor- based clinical study was conducted on 60 patients of mild-to-moderate erosive GERD. After baseline clinical assessment and investigations, rabeprazole (40 mg) was prescribed to 30 patients and esomeprazole (40 mg) to another 30 patients for 4 weeks. The effi cacy variables were change in GERD symptom scoring, endoscopic fi ndings, and Quality of Life in Refl ux and Dyspepsia (QOLRAD) scoring over 4 weeks. Result: Heartburn, acid regurgitation, and overall GERD symptom scoring (P = 0.01) were signifi cantly decreased with rabeprazole in comparison to esomeprazole. The comparative study of all fi ve domains of the QOLARD questionnaire including overall scoring revealed a statistically signifi cant improvement in the rabeprazole group. Endoscopic fi ndings in the rabeprazole group showed an absolute improvement of 30% and relative improvement of 55% over esomeprazole. Both the drugs were well tolerated having no signifi cant difference in the incidence of adverse effects. Conclusion: Rabeprazole (40 mg) is a better choice for mild-to-moderate GERD compared with esomeprazole (40 mg) because of its better effi cacy and safety profi le.
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Maiti, R., Jaida, J., Israel, P. L. J., Koyagura, N., & Mukkisa, S. (2011). Rabeprazole and esomeprazole in mild-to-moderate erosive gastroesophageal reflux disease: A comparative study of efficacy and safety. Journal of Pharmacology and Pharmacotherapeutics, 2(3), 150–157. https://doi.org/10.4103/0976-500X.83278