A case of tinnitus induced by chlorpromazine in a pediatric patient
Carla Carnovale2, Paolo Pellegrino2, Silvia Beretta3, Gian Vincenzo Zuccotti3, Valentina Perrone2, Stefania Antoniazzi2, Marco Pozzi4, Emilio Clementi2,4, Sonia Radice2★★ Corresponding author
- 1Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital.
- 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Milan.
- 3Scientific Institute for Research, Hospitalization and Health Care Eugenio Medea, Bosisio Parini, Lecco, Italy Case Report.
CORRESPONDENCE
Sonia Radice
Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Milan.
Received: 02-05-2013; Revised: 29-06-2013; Accepted: 01-11-2013.
Volume 5, Issue 2 · pp. 163–165 · PUBLISHED 2014 · DOI: 10.4103/0976-500X.130110
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ABSTRACT
Chlorpromazine is a well‑known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12‑year‑old boy, affected by severe generalized anxiety disorder. After treatment with chlorpromazine, the patient experienced an enhanced sensitivity to sounds accompanied by perception of noises of the buzzing or ringing type. This clinical case is of great clinical interest as chlorpromazine is not currently included among potentially ototoxic drugs.
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Carnovale, C., Pellegrino, P., Beretta, S., Zuccotti, G. V., Perrone, V., Antoniazzi, S., Pozzi, M., Clementi, E., & Radice, S. (2014). A case of tinnitus induced by chlorpromazine in a pediatric patient. Journal of Pharmacology and Pharmacotherapeutics, 5(2), 163–165. https://doi.org/10.4103/0976-500X.130110