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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis

    Raffaele Serra1★, Raffaele Grande1, Gianluca Buffone1, Edoardo Scarcello2, Fabio Tripodi3, Pierandrea Rende4, Luca Gallelli4, Stefano de Franciscis1★ Corresponding author

    1. 1Departments of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
    2. 2Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy.
    3. 3Department of Pharmacological, Biological and Chemical Science, University of Parma, Parma, Italy.
    4. 4Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy.

    CORRESPONDENCE

    Raffaele Serra

    Departments of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.

    Received: 13-01-2014; Revised: 08-02-2014; Accepted: 15-02-2014.

    Volume 5, Issue 3 · pp. 193–196 · PUBLISHED 2014 · DOI: 10.4103/0976-500X.136101

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor‑alpha inhibitors in patients with Takayasu arteritis (TA). Materials and Methods: In five patients with TA, the effects of the sequential treatment with prednisone for 5‑7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated. Results: All treatments improved both symptoms and laboratory parameters without the development of side‑effects. Conclusions: It was hypothesized that MMP‑9 and neutrophil gelatinase‑associated lipocalin could be markers of the response to the treatments.

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      Serra, R., Grande, R., Buffone, G., Scarcello, E., Tripodi, F., Rende, P., Gallelli, L., & Franciscis, S. D. (2014). Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis. Journal of Pharmacology and Pharmacotherapeutics, 5(3), 193–196. https://doi.org/10.4103/0976-500X.136101