Hypoglycemia, polycythemia and hyponatremia in a newborn exposed to nebivolol during pregnancy
Maria Giuseppa Sullo1★, Domenico Perri2, Michelina Sibilio2, Concetta Rafaniello1, Annamaria Fucile1★ Corresponding author
- 1Francesco Rossi, Annalisa Capuano Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Centre of the Campania Region, Second University of Naples, Naples, Italy.
- 2Department of Pediatric, Moscati Hospital, Aversa, 2 Azienda Sanitaria Locale Di Caserta, Caserta, Italy.
CORRESPONDENCE
Maria Giuseppa Sullo
Francesco Rossi, Annalisa Capuano Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Centre of the Campania Region, Second University of Naples, Naples, Italy.
Received: 04-02-2014; Revised: 15-03-2014; Accepted: 28-06-2014.
Volume 6, Issue 1 · pp. 45–48 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.149148
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ABSTRACT
Nebivolol is a third‑generation beta blocker that exerts selective antagonistic activity on β1 receptors. It has vasodilating properties that result from direct stimulation of endothelial nitric oxide synthase. Nebivolol is indicated for the treatment of hypertension and heart failure, and is generally well tolerated. In this article, we report a case of an infant who was admitted to the Pediatrics and Neonatology Unit of the Moscati Hospital (Aversa, Italy) about 24 hours after birth. The reason for hospitalization was persistent severe hypoglycemia (blood glucose = 30 mg/dL) and jaundice (total bilirubin = 12.5 mg/dL, indirect bilirubin 11.75 mg/dL). He was born by spontaneous delivery after a normal term pregnancy. Birth weight was 3040 g and the Apgar score was 6‑9. The mother reported taking nebivolol 5 mg/day for unspecified tachycardia in the last 4 months of pregnancy. Clinical and instrumental investigations carried out during hospitalization did not reveal any congenital or perinatal abnormalities. After treatment for metabolic and electrolyte imbalance, he was discharged on the 10th day of hospitalization, in good clinical condition and with normalization of clinical and laboratory parameters. Currently, there are no specific studies on nebivolol tolerability during pregnancy. Our data suggest that the risk profile of nebivolol during pregnancy is the same as that of other β‑blockers. Therefore, further studies are required to determine the safety of β‑blockers during pregnancy and the risks to the unborn child.
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Sullo, M. G., Perri, D., Sibilio, M., Rafaniello, C., & Fucile, A. (2015). Hypoglycemia, polycythemia and hyponatremia in a newborn exposed to nebivolol during pregnancy. Journal of Pharmacology and Pharmacotherapeutics, 6(1), 45–48. https://doi.org/10.4103/0976-500X.149148