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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled Trial

    Maaz Hussain Syed1★, Prakash Narayan Khandelwal2, Vijay R. Thawani3, S. S. Katare4★ Corresponding author

    1. 1Department of Pharmacology, Indian Institute of Medical Science and Research and Noor Hospital, Jalna, India.
    2. 2Department of Pharmacology, Government Medical College and Hospital, Aurangabad, India.
    3. 3Department of Pharmacology, People’s College of Medical Sciences and Research Centre, Bhopal, India.
    4. 4Department of Pharmacology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital, Pune, Maharashtra, India.

    CORRESPONDENCE

    Maaz Hussain Syed

    Department of Pharmacology, Indian Institute of Medical Science and Research and Noor Hospital, Jalna, India.

    drmaaz4u@gmail.com

    Received: 06-10-2016; Revised: 29-12-2016; Accepted: 14-03-2017.

    Volume 8, Issue 2 · pp. 50–3 · PUBLISHED 1 April 2017 · DOI: 10.4103/jpp.JPP_156_16

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph. Materials and Methods: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography. Results: A total of 160 patients completed the trial. Postprocedure, nine and two CIN cases were found in Group A and B, respectively. The mean change in serum creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was statistically significant (P = 0.0289). Postprocedure, the estimated glomerular filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P = 0.003). Conclusion: This trial indicates the positive role of statins in preventive strategy against CIN along with NAC.

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      Syed, M. H., Khandelwal, P. N., Thawani, V. R., & Katare, S. S. (2017). Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled Trial. Journal of Pharmacology and Pharmacotherapeutics, 8(2), 50–3. https://doi.org/10.4103/jpp.JPP_156_16