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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Treatment Outcome of Ovulation‑inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study

    Kinjal Prajapati1★, Mira Desai1, Samidh Shah1, Sumesh Choudhary2, Rohina Aggarwal2, Vineet Mishra2★ Corresponding author

    1. 1Department of Pharmacology, B.J. Medical College, India.
    2. 2Department of Obstetrics and Gynaecology, Institute of Kidney Diseases and Research Center, Civil Hospital, Ahmedabad, Gujarat, India.

    CORRESPONDENCE

    Kinjal Prajapati

    Department of Pharmacology, B.J. Medical College, India.

    drkinjal. 7290@gmail.com

    Received: 20-03-2017; Revised: 17-06-2017; Accepted: 24-07-2017.

    Volume 8, Issue 3 · pp. 116–121 · PUBLISHED 2017 · DOI: 10.4103/jpp.JPP_43_17

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To compare different treatment regimens on pregnancy rate and outcome in patients with anovulatory infertility. Patients and Methods: A prospective observational study was conducted on patients with infertility due to anovulation. Patients treated with clomiphene citrate (CC) 50/100 mg/day from 2nd to 6th day of menstrual cycle (MC) (n = 38), short gonadotropin‑releasing hormone (GnRH) agonist regimen (leuprolide [0.5 mg subcutaneous] + recombinant follicle‑stimulating hormone [rFSH] [225 IU intramuscular [IM]] from 2nd to 10th day of MC [n = 32]), long GnRH agonist regimen (leuprolide from 21st day followed by leuprolide + rFSH from 2nd to 10th day of MC [n = 19]), and antagonist regimen (human menopausal gonadotropin [hMG] [150 IU IM] from 2nd day followed by hMG + cetrorelix from 7th to 10th day of MC) (n = 6) were recruited and followed up for follicular size, endometrial thickness, and pregnancy test. Data were analyzed using appropriate statistical test and P < 0.05 was considered statistically significant. Results: A significant increase in follicular diameter and endometrial thickness was observed in patients treated with gonadotropin regimens as compared to CC alone (P < 0.0001). The highest number of positive pregnancy test with ultrasonographic evidence of gestational sac was observed with leuprolide + rFSH (long regimen) (10/19, 52.6%) followed by leuprolide + rFSH (short regimen) (13/32, 40.6%) while least in antagonist regimen (2/6, 33.3%) and CC (1/38, 2.63%). All regimens were well tolerated. Conclusion: Treatment outcome was better with long agonist regimen.

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      Prajapati, K., Desai, M., Shah, S., Choudhary, S., Aggarwal, R., & Mishra, V. (2017). Treatment Outcome of Ovulation‑inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study. Journal of Pharmacology and Pharmacotherapeutics, 8(3), 116–121. https://doi.org/10.4103/jpp.JPP_43_17