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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Effect of Coexisting Hypertension, Blood Pressure Control, and Antihypertensive Treatment on QT Interval Parameters in Type 2 Diabetics: A Cross‑Sectional Study

    Jayesh Dalpatbhai Solanki1★, Kruti J. Patel2, Nisha Lalwani3, Hemant B. Mehta1, Chinmay J. Shah1, Matika N. Lakhtaria2★ Corresponding author

    1. 1Department of Physiology, College, Bhavnagar, Gujarat, India.
    2. 2Undergraduate Student and, India.
    3. 3Medicine, Government Medical College, Bhavnagar, Gujarat, India.

    CORRESPONDENCE

    Jayesh Dalpatbhai Solanki

    Department of Physiology, College, Bhavnagar, Gujarat, India.

    drjaymin_83@yahoo.com

    Received: 01-11-2017; Revised: 28-01-2018; Accepted: 05-06-2018.

    Volume 9, Issue 1 · pp. 21–26 · PUBLISHED 2018 · DOI: 10.4103/jpp.JPP_139_17

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objectives: To study the electrocardiogram (ECG) based QT parameters namely QTc (heart rate corrected QT), QTd (QT dispersion) in treated type 2 diabetics (T2D) and the effect of hypertension (HTN), blood pressure (BP) control, and antihypertensives used on the above parameters. Materials and Methods: We performed a cross‑sectional study in a tertiary care hospital of Gujarat, India, on 199 T2D (67 males and 132 females). Standard 12‑lead ECG was recorded to derive QTc (Bazett’s formula), QTd, and ECG left ventricular hypertrophy (LVH). QTc >0.43 s in male and >0.45 s in female and QTd >80 msec were considered abnormal. Results: Hypertensives (n = 138) and normotensives (n = 61) were comparable for most confounders. Hypertensives had better profile of QTc and QTd than normotensives. T2D with controlled BP revealed slightly better, though insignificant; QTc, QTd than those with BP uncontrolled. QT parameters were not significantly correlated with age, heart rate, or BP. Qualitative differences exceeded quantitative difference in QTc and QTd evaluation. There was no significant effect of use or nonuse of preventive pharmacotherapy on QT parameters. Conclusion: Low‑to‑moderate prevailing cardiac repolarization abnormality in T2D with very low ECG LVH was unaffected by HTN as a disease, its control status, and treatment modalities suggesting primary preventive role of antihypertensive use without class difference.

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      Solanki, J. D., Patel, K. J., Lalwani, N., Mehta, H. B., Shah, C. J., & Lakhtaria, M. N. (2018). Effect of Coexisting Hypertension, Blood Pressure Control, and Antihypertensive Treatment on QT Interval Parameters in Type 2 Diabetics: A Cross‑Sectional Study. Journal of Pharmacology and Pharmacotherapeutics, 9(1), 21–26. https://doi.org/10.4103/jpp.JPP_139_17