Volume 7, Issue 1

Commentary

1. Article

   Abuse of topical corticosteroids in India: Concerns and the way forward

   Subodh Kumar, Aman Goyal, Yogendra Kumar Gupta

   pp. 1–2 · DOI: 10.4103/0976-500X.179364 · Published 2016

   Topical corticosteroids (TCs) are among the most commonly used medications in dermatology clinics.[1] They are highly efficacious drugs which are used for the treatment of varied autoimmune and inflammatory dermatologica…

Research Paper

1. Article

   Variability in plasma concentration of cefotaxime in critically ill patients in an Intensive Care Unit of India and its pharmacodynamic outcome: A nonrandomized, prospective, open‑label, analytical study

   B. Abhilash, Chakra Dhar Tripathi, Anoop Raj Gogia, Girish Gulab Meshram, Manu Kumar, B. Suraj

   pp. 15–21 · DOI: 10.4103/0976-500X.179356 · Published 2016

   Background: Cefotaxime is a widely utilized cephalosporin in most intensive care units of India. However, no data are available about its pharmacokinetic/pharmacodynamic variability in critically ill patients of the Indi…

2. Article

   Asenapine modulates nitric oxide release and calcium movements in cardiomyoblasts

   Elena Grossini, Carla Gramaglia, Serena Farruggio, Lara Camillo, David Mary, Giovanni Vacca, Patrizia Zeppegno

   pp. 6–14 · DOI: 10.4103/0976-500X.179358 · Published 2016

   Objective: To examine the effects of asenapine on nitric oxide (NO) release and Ca2+ transients in H9C2 cell line, which were either subjected to peroxidation or not. Materials and Methods: H9C2 were treated with asenapi…

Research Letter

1. Article

   Inhibition of astrocyte activation is involved in the prevention of postoperative latent pain sensitization by ketamine and gabapentin in mice

   Elizabeth Romero-Alejo, Margarita M. Puig, Asunción Romero

   pp. 22–4 · DOI: 10.4103/0976-500X.179357 · Published 2016

   The pharmacologic management of postoperative pain has currently a double purpose: On one hand to reduce the intensity of the acute pain after surgery, and, on the other hand, to prevent the development of chronic postsu…

2. Article

   Nonsteroidal anti-inflammatory drugs causing local inflammation of tissue at the site of injection

   Anton Aleksandrovich Kasatkin, Alexandr A. Urakov, Ilya Aleksandrovich Lukoyanov

   pp. 26–8 · DOI: 10.4103/0976-500X.179359 · Published 2016

   Injections of drug solutions can be followed by the development of local complications such as phlebitis, cellulitis, phlegmon, and necrosis. The development of these complications is not precluded by medical personnel’s…

3. Article

   Incidence of metabolic syndrome in breast cancer survivors on adjuvant hormonal therapy

   Anahita Kate, Dharanipragada Kadambari

   pp. 28–30 · DOI: 10.4103/0976-500X.179362 · Published 2016

   The increasing incidence of breast cancer in Indian women has been coupled with a significant rise in the population of breast cancer survivors, particularly among women with estrogen receptor-positive tumors. There is g…

4. Article

   Evaluation of inter-rater agreement between three causality assessment methods used in pharmacovigilance

   Saket J. Thaker, Rahul S. Sinha, Nithya J. Gogtay, Urmila M. Thatte

   pp. 31–3 · DOI: 10.4103/0976-500X.179361 · Published 2016

   Causality assessment is the evaluation of a possibility that a particular treatment is the cause of an adverse event. It plays a key role in pharmacovigilance both toward signal generation and risk benefit evaluation. Th…

Case Report

1. Article

   “Ping‑pong gaze” secondary to monoamine oxidase inhibitor overdose

   Amy Attaway, Laila Sroujieh, Tracey L. Mersfelder, Christopher Butler, Daniel Ouellette

   pp. 34–37 · DOI: 10.4103/0976-500X.179360 · Published 2016

   An infrequent manifestation of monoamine oxidase inhibitor (MAOI) toxicity is “ping-pong gaze” (PPG). We describe the case of a 26-year-old female who was found unresponsive after taking 40 tablets of phenelzine. On pres…

2. Article

   Tamoxifen‑induced hypertriglyceridemia causing acute pancreatitis

   Hemant Kumar Singh, Mahendranath S. Prasad, Arun K. Kandasamy, Kadambari Dharanipragada

   pp. 38–40 · DOI: 10.4103/0976-500X.179365 · Published 2016

   Tamoxifen has both antagonistic and agonistic tissue‑specific actions. It can have a paradoxical estrogenic effect on lipid metabolism resulting in elevated triglyceride and chylomicron levels. This can cause life‑threat…

3. Article

   Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction

   Vaneet Jearath, Rajan Vashisht, Vipul Rustagi, Sujeet Raina, Rajesh Sharma

   pp. 41–3 · DOI: 10.4103/0976-500X.179363 · Published 2016

   Pioglitazone‑induced heart failure is known in patients with underlying heart disease, but is not well documented in patients with normal left ventricular function. Pioglitazone has been very popular as it is an insulin …

4. Article

   Acute compartment syndrome of hand resulting from radiographic contrast iohexol extravasation

   Kolar Vishwanath Vinod, Rampelli Shravan, Radhakrishnan Shrivarthan, Pedapati Radhakrishna

   pp. 44–47 · DOI: 10.4103/0976-500X.179353 · Published 2016

   Intravenous (IV) administration of iodinated contrast agents (ICAs) is frequently employed for image enhancement while performing radiographic studies such as computed tomography and angiography. Complications related to…

Correspondence

1. Article

   Exercise-induced urticaria, cholinergic urticaria, and Kounis syndrome

   Nicholas G. Kounis, George N. Kounis, George D. Soufras

   pp. 48–50 · DOI: 10.4103/0976-500X.179355 · Published 2016

   Physical exercise may provoke the onset of clinical symptoms that are usually associated with an allergic reaction. Distinct forms of recognized physical allergies are exercise-induced anaphylaxis (EIA), food-dependent E…

1. Article

   A closer look at the World Health Organization’s prescribing indicators Richard Ofori‑Asenso

   Research Unit, Health Policy Consult, Weija Weija, Accra Accra, Ghana Ghana

   pp. 51–54 · DOI: 10.4103/0976-500X.179352 · Published 2016

   This communication focuses on the World Health Organization’s prescribing indicators. It describes the methods for computing the indicators and highlights their applicability as well as limitations in evaluating the patt…

Book Review

1. Article

   Pathophysiology and pharmacology of cardiovascular disease

   Raja J. Selvaraj

   pp. 55–55 · DOI: · Published 2016