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    Pharmacognosy CommunicationsNOW IN
    Article

    Citrus australasica F. Muell. Leaf Extracts are Ineffective Inhibitors of the Growth of a Panel of Bacterial Pathogens

    Lindy Mpala1, Getmore Chikowe1, Ian E Cock1,2★★ Corresponding author

    1. 1School of Environment and Science, Nathan Campus, Griffith University, Brisbane, Queensland, AUSTRALIA.
    2. 2Centre for Planetary Health and Food Security, Griffith University, Brisbane, Queensland, AUSTRALIA.

    CORRESPONDENCE

    Ian E Cock

    School of Environment and Science, Nathan Campus, Griffith University, Brisbane, Queensland, AUSTRALIA.

    i.cock@griffith.edu.au

    Volume 12, Issue 4 · pp. 126–131 · PUBLISHED · DOI: 10.5530/pc.2022.4.26

    View on Pharmacogn. Commn. original site ↗

    ABSTRACT

    Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a genus are known to possess therapeutic properties. The genus Citrus has a long history of ethnobotanbical usage in many areas of the world. Many species are known to have therapeutic properties, several species of which have well established antibacterial bioactivities. Materials and Methods :The ability of Citrus australasica F. Muell. leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: The C. australasica methanolic and aqueous extracts were ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria and were nontoxic in the Artemia lethality assay following 24 hr exposure. Conclusion: Despite its close taxonomic relationship with several bioactive Citrus spp. with antibacterial activity, C. australasica leaf extracts were ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.

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      Mpala, L., Chikowe, G., & Cock, I. E. (). Citrus australasica F. Muell. Leaf Extracts are Ineffective Inhibitors of the Growth of a Panel of Bacterial Pathogens. Pharmacognosy Communications, 12(4), 126–131. https://doi.org/10.5530/pc.2022.4.26