Corilagin: First Time Isolation from the Whole Plant of Phyllanthus maderaspatensis L.
Abhilash Kochumadhavan1, Priyanka Mangal1, LM Sharath Kumar1, Badugu Madhura Meenakshi1, Babu Uddagiri Venkanna1, Ganesh Muguli1★★ Corresponding author
- 1R&D Centre, The Himalaya Drug Company, Bengaluru, Karnataka, INDIA.
CORRESPONDENCE
Ganesh Muguli
R&D Centre, The Himalaya Drug Company, Bengaluru, Karnataka, INDIA.
Volume 9, Issue 4 · pp. 135–138 · PUBLISHED · DOI: 10.5530/pc.2019.4.28
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ABSTRACT
Introduction: Corilagin, an ellagitannin (chemical name β-1-O-galloyl-3,6- (R)-hexahydroxydiphenoyl-d-glucose), was previously reported from other species of Phyllanthus except Phyllanthus maderaspatensis L. Therefore, the aim of the study was to isolate corilagin from P. maderaspatensis and report it as chemo-marker. Methods: The whole plant of P. maderaspatensis was subjected to hot extraction and partitioning, followed by repeated column chromatography (silica, Diaion HP-20 and Prep HPLC). The observed LC‑MS/MS and NMR data were compared with reported literature to verify the structure of the isolated molecule as corilagin. Results: The LC-MS/MS chromatogram showed a peak at retention time 22.05 min, with m/z 633 for [M - H]− along with characteristic major fragments at m/z 463 [M - 170 - H]− and m/z 301 [M - 332 - H]−. The NMR results were also in accordance with literature. Conclusion: This is the first report on isolation of corilagin from P. maderaspatensis whole plant for standardization and quality control of the plant.
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Kochumadhavan, A., Mangal, P., Kumar, L. S., Meenakshi, B. M., Venkanna, B. U., & Muguli, G. (). Corilagin: First Time Isolation from the Whole Plant of Phyllanthus maderaspatensis L.. Pharmacognosy Communications, 9(4), 135–138. https://doi.org/10.5530/pc.2019.4.28