Exploration of Phytochemicals Found in Terminalia sp. and their Antiretroviral Activities
Alka Dwevedi1★, Raman Dwivedi2, Yogesh K Sharma3★ Corresponding author
- 1Department of Environmental Sciences, Sri Aurobindo College, University of Delhi, INDIA.
- 2Department of Polymer Sciences, Delhi Technological University, INDIA.
- 3Department of Chemistry, Swami Shraddhanand College, University of Delhi, New Delhi, INDIA.
CORRESPONDENCE
Alka Dwevedi
Department of Environmental Sciences, Sri Aurobindo College, University of Delhi, INDIA.
Volume 10, Issue 20 · pp. 73–83 · PUBLISHED · DOI: 10.4103/0973-7847.194048
View on Pharmacogn. Rev. original site ↗
ABSTRACT
The human immunodeficiency virus (HIV) infects cells of the immune system and destroys their function. Approximately, 2 million people die every year from HIV as reported by the World Health Organization. HIV/AIDS is difficult to treat as the virus continuously develops resistance to drugs being developed. Approach is now turning toward natural products for the development of anti-HIV drugs. Although HIV/AIDS is not a new disease, but research based on plant-derived products is still under clinical trials. Experimentally, it has been proven that plants have the potential for HIV treatment. The process involves identification of the active ingredients responsible for the reported anti-HIV activities, testing of the extract, and development of appropriate bioassays. Further development would require optimization of the formulation and manufacturing in compliance with preclinical safety and efficacy testing. The most challenging task for the natural product scientists is to separate these highly complex extracts containing several compounds into its individual components that are biologically active. Recently developed direct binding assay with mass spectrometry (MS) technology (viz., real-time time-of-flight-MS) is helpful in this respect but needs extensive optimization. At present, we have compiled all the information for the various phytochemicals present in Terminalia catappa having anti-HIV properties. These include tannins, gallotannins, ellagitannins, cyanidin, and flavonoids. Further, we have also discussed their pharmacological as well as pharmacokinetics studies.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Dwevedi, A., Dwivedi, R., & Sharma, Y. K. (). Exploration of Phytochemicals Found in Terminalia sp. and their Antiretroviral Activities. Pharmacognosy Reviews, 10(20), 73–83. https://doi.org/10.4103/0973-7847.194048