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    Plants’ Natural Products as Alternative Promising Anti‑Candida Drugs

    Sameh Soliman1,2★, Dina Alnajdy1, Ali A. El‑Keblawy3, Kareem A. Mosa3,4, Ghalia Khoder5, Ayman M. Noreddin6,7★ Corresponding author

    1. 1Departments of Medicinal Chemistry.
    2. 2Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig.
    3. 3Department of Applied Biology, University of Sharjah, Sharjah, United Arab Emirates.
    4. 4Department of Biotechnology, Faculty of Agriculture, Al‑Azhar University, Cairo, EGYPT.
    5. 5Pharmaceutics and Pharmaceutical Technology.
    6. 6Pharmacy Practice and Pharmacotherapy, College of Pharmacy, University of Sharjah.
    7. 7Department of Pharmacy Practice, School of Pharmacy, Chapman University, Irvine, California, USA.

    CORRESPONDENCE

    Sameh Soliman

    Departments of Medicinal Chemistry.

    ssoliman@sharjah.ac.ae

    Volume 11, Issue 22 · pp. 104–122 · PUBLISHED · DOI: 10.4103/phrev.phrev_8_17

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    Candida is a serious life‑threatening pathogen, particularly with immunocompromised patients. Candida infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. Candida infections are common in hospitalized patients and elderly people. The difficulty to eradicate Candida infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines. Several plants show significant anti‑Candida activities and some of them have lower minimum inhibitory concentration, making them promising candidates for anti‑Candida therapy. However, none of these plant products is marketed for anti‑Candida therapy because of lack of sufficient information about their efficacy, toxicity, and kinetics. This review revises major plants that have been tested for anti‑Candida activities with recommendations for further use of some of these plants for more investigation and in vivo testing including the use of nanostructure lipid system.

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      Soliman, S., Alnajdy, D., El‑Keblawy, A. A., Mosa, K. A., Khoder, G., & Noreddin, A. M. (). Plants’ Natural Products as Alternative Promising Anti‑Candida Drugs. Pharmacognosy Reviews, 11(22), 104–122. https://doi.org/10.4103/phrev.phrev_8_17