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    Phytochemical Survey and Pharmacological Activities of the Indole Alkaloids in the Genus Voacanga Thouars (Apocynaceae) – An Update

    Allan Patrick G. Macabeo1,3★, Grecebio Jonathan D. Alejandro2, Arnold V. Hallare4, Warren S. Vidar1, Oliver B. Villaflores1★ Corresponding author

    1. 1Phytochemistry, Research Center for the Natural Sciences, University of Santo Tomas, Espana Blvd, Manila 1015, PHILIPPINES.
    2. 2Plant Sciences, Research Center for the Natural Sciences, University of Santo Tomas, Espana Blvd, Manila 1015, PHILIPPINES.
    3. 3Institut für Organische Chemie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, GERMANY.
    4. 4Department of Biology, CAS, University of the Philippines-Manila, Padre Faura St., Manila 1000, PHILIPPINES.

    CORRESPONDENCE

    Allan Patrick G. Macabeo

    Phytochemistry, Research Center for the Natural Sciences, University of Santo Tomas, Espana Blvd, Manila 1015, PHILIPPINES.

    allan-patrick.macabeo@chemie.uni-regensburg.de

    Volume 3, Issue 5 · pp. 143–153 · PUBLISHED · DOI:

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    Numerous species of the Apocynaceous genus Voacanga Thouars have been demonstrated to elaborate a host of indole alkaloids that display various structural complexities and a wide array of biological activities. Monoterpenoid indole alkaloids are nitrogenous metabolites borne from the biosynthetic union of tryptophan and the terpene-derived iridoid, secologanin. As a genus is closely related to Tabernaemontana, representative species of Voacanga were reported to contain the vobasine, vallesamine, eburnane, iboga and aspidosperma–type indole alkaloids. A lot of these compounds are associated with analgesic, CNS, antimicrobial, anti-ulcer, cytotoxic, antioxidant and antimalarial activities. Voacanga is a small taxon with 12 species that are mainly found in tropical Africa and Malesia except for V. grandifolia which extends to Australia. This comprehensive review compiles the phytochemical and pharmacological explorations that have been undertaken on Voacanga in relation to its indole alkaloids.

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      Macabeo, A. P. G., Alejandro, G. J. D., Hallare, A. V., Vidar, W. S., & Villaflores, O. B. (). Phytochemical Survey and Pharmacological Activities of the Indole Alkaloids in the Genus Voacanga Thouars (Apocynaceae) – An Update. Pharmacognosy Reviews, 3(5), 143–153.