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    In vitro production of alkaloids: Factors, approaches, challenges and prospects

    Sayeed Ahmad1★, Madhukar Garg1, Ennus Tajuddin Tamboli1, M. Z. Abdin2, S. H. Ansari1★ Corresponding author

    1. 1Department of Pharmacognosy and Phytochemistry, Bioactive Natural Product Laboratory, INDIA.
    2. 2Department of Biotechnology, Jamia Hamdard, Hamdard University, New Delhi, INDIA.

    CORRESPONDENCE

    Sayeed Ahmad

    Department of Pharmacognosy and Phytochemistry, Bioactive Natural Product Laboratory, INDIA.

    sahmad_jh@yahoo.co.in

    Received: 09-08-2012; Revised: 17-08-2012; Accepted: 06-05-2013.

    Volume 7, Issue 13 · pp. 27–33 · PUBLISHED 1 June 2013 · DOI: 10.4103/0973-7847.112837

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    The wide diversity of plant secondary metabolites is largely used for the production of various pharmaceutical compounds. In vitro cell tissue or organ culture has been employed as a possible alternative to produce such industrial compounds. Tissue culture techniques provide continuous, reliable, and renewable source of valuable plant pharmaceuticals and might be used for the large‑scale culture of the plant cells from which these secondary metabolites can be extracted. Alkaloids are one of the most important secondary metabolites known to play a vital role in various pharmaceutical applications leading to an increased commercial importance in recent years. The tissue culture techniques may be utilized to improve their production of alkaloids via somaclonal variations and genetic transformations. The focus of this review is toward the application of different tissue culture methods/techniques employed for the in vitro production of alkaloids with a systematic approach to improve their production.

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      Ahmad, S., Garg, M., Tamboli, E. T., Abdin, M. Z., & Ansari, S. H. (2013). In vitro production of alkaloids: Factors, approaches, challenges and prospects. Pharmacognosy Reviews, 7(13), 27–33. https://doi.org/10.4103/0973-7847.112837