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    Cholinesterase inhibitors from botanicals

    Faiyaz Ahmed1★, Raza Murad Ghalib2, P. Sasikala1, K. K. Mueen Ahmed3★ Corresponding author

    1. 1Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, INDIA.
    2. 2Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, MALAYSIA.
    3. 3Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, KINGDOM OF SAUDI ARABIA.

    CORRESPONDENCE

    Faiyaz Ahmed

    Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, INDIA.

    faiyazahmed@iicpt.edu.in

    Received: 26-02-2013; Revised: 07-03-2013.

    Volume 7, Issue 14 · pp. 121–130 · PUBLISHED · DOI: 10.4103/0973-7847.120511

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    Alzheimer’s disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Consequently, researches have focused their attention towards finding cholinesterase inhibitors from natural products. A large number of such inhibitors have been isolated from medicinal plants. This review presents a comprehensive account of the advances in field of cholinesterase inhibitor phytoconstituents. The structures of some important phytoconstituents (collected through www.Chemspider.com) are also presented and the scope for future research is discussed.

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      Ahmed, F., Ghalib, R. M., Sasikala, P., & Ahmed, K. K. M. (). Cholinesterase inhibitors from botanicals. Pharmacognosy Reviews, 7(14), 121–130. https://doi.org/10.4103/0973-7847.120511