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    Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus

    Jianhua Zhu1, Mingxuan Wang1, Wei Wen1, Rongmin Yu1,2★★ Corresponding author

    1. 1Biotechnological Institute of Chinese Materia Medica.
    2. 2Department of Natural Medicinal Chemistry, College of Pharmacy, Jinan University, Guangzhou 510632, CHINA.

    CORRESPONDENCE

    Rongmin Yu

    Biotechnological Institute of Chinese Materia Medica.

    tyrm@jnu.edu.cn

    Received: 13-06-2014; Revised: 16-09-2014; Accepted: 05-05-2015.

    Volume 9, Issue 17 · pp. 24–28 · PUBLISHED · DOI: 10.4103/0973-7847.156323

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    Catharanthus roseusproduces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia. The TIA biosynthetic pathway has been investigated for many years, for scientific interest and for their potential in manufacturing applications, to fulfill the market demand. In this review, the progress and perspective of C. roseus TIA biosynthesis and its regulating enzymes are described. In addition, the culture condition, hormones, signaling molecules, precursor feeding on the accumulation of TIA, and gene expression are also evaluated and discussed.

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      Zhu, J., Wang, M., Wen, W., & Yu, R. (). Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus. Pharmacognosy Reviews, 9(17), 24–28. https://doi.org/10.4103/0973-7847.156323