Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells
Jin Bae Weon2, Bohyoung Lee2, Bo-Ra Yun2, Jiwoo Lee2, Choong Je Ma2,3★★ Corresponding author
- 1Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University.
- 2Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea.
CORRESPONDENCE
Choong Je Ma
Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea.
Received: 27-09-2012; Revised: 11-11-2012.
phm-v10-i38 · pp. 161–164 · PUBLISHED 17 April 2014 · DOI: 10.4103/0973-1296.131028
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ABSTRACT
Background: Cynanchum paniculatum, belongs to the family Asclepiadaceae and is used to treat various diseases, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time. Materials and Methods: 4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of C. paniculatum and its neuroprotective effect was evaluated by MTT assay. Results: 4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells. Conclusion: Furthermore, we found that reactive oxygen species (ROS) accumulation and calcium concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.
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Weon, J. B., Lee, B., Yun, B., Lee, J., & Ma, C. J. (2014). Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells. Pharmacognosy Magazine, , 161–164. https://doi.org/10.4103/0973-1296.131028