Antidepressant‑like effects of Chaihu‑Shugan‑San via SAPK/JNK signal transduction in rat models of depression
Yun‑Hui Li1★, Chun‑Hu Zhang1, Juan Qiu1, Su‑E Wang1, Sui‑Yu Hu1, Xi Huang1, Ying Xie1, Yang Wang1★ Corresponding author
- 1Tian‑Li Cheng Institute of Integrated Traditional Chinese and Western Medicine, Key Laboratory of Traditional Chinese Medicine Gan Organ of SATCM, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008 Changsha, PR, China.
CORRESPONDENCE
Yun‑Hui Li
Tian‑Li Cheng Institute of Integrated Traditional Chinese and Western Medicine, Key Laboratory of Traditional Chinese Medicine Gan Organ of SATCM, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008 Changsha, PR, China.
Received: 27-06-2013; Revised: 17-08-2013.
phm-v10-i39 · pp. 271–277 · PUBLISHED 24 July 2014 · DOI: 10.4103/0973-1296.137367
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ABSTRACT
Background: Chaihu‑Shugan‑San (CHSGS), a traditional Chinese medicinal herbal formula, registered in Jingyue Quanshu, has been indicated that oral administration of the extract from it can remit depressive disorder. C‑Jun amino‑terminal kinase (JNK/SAPK) signal transduction plays a key role in the apoptosis of nerve cells, be reported closely correlated with depression. This study was designed to investigate CHSGS antidepressant‑like effects in rat models of depression and probe its possible mechanism. Materials and Methods: The classical experimental depression model chronic mild unpredictable stress (CMUS) was used to evaluate the antidepressant‑like effects of CHSGS. The extracts were administered orally for 14 days, while the parallel positive control was given at the same time using fluoxetine hydrochloride. The expressions of JNK in the hippocampus were detected by real‑time fluorescent quantitation PCR and Western blot assay. Results: Intragastric administration of CHSGS for 14 days caused a significant improvement of weight and locomotor activity in the open‑field test. In addition, CHSGS treatment inhibited the expressions of JNK in the hippocampus tissue in CMUS rats. Conclusion: CHSGS could obviously improve the depressive state of the model rats and its mechanism may be correlated with regulating the expressions of JNK in the hippocampus.
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Li, Y., Zhang, C., Qiu, J., Wang, S., Hu, S., Huang, X., Xie, Y., & Wang, Y. (2014). Antidepressant‑like effects of Chaihu‑Shugan‑San via SAPK/JNK signal transduction in rat models of depression. Pharmacognosy Magazine, , 271–277. https://doi.org/10.4103/0973-1296.137367