Inhibitory effects of ginseng seed on melanin biosynthesis
Yeonmi Lee1★, Kyoung‑Tack Kim1, Sung Soo Kim1, Jinyoung Hur1, Sang Keun Ha1, Chang‑Won Cho1★ Corresponding author
- 1Sang Yoon Choi Korea Food Research Institute, Seongnam 463‑746, Republic of Korea.
CORRESPONDENCE
Yeonmi Lee
Sang Yoon Choi Korea Food Research Institute, Seongnam 463‑746, Republic of Korea.
Received: 20-08-2013; Revised: 14-09-2013.
phm-v10-i38 · pp. 272–275 · PUBLISHED 28 May 2014 · DOI: 10.4103/0973-1296.133271
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ABSTRACT
Background: Ginseng root has been traditionally used for the treatment of many diseases in Korea. However, so far ginseng seed has been mostly unused and discarded. As part of our ongoing research on the ginseng seeds, the inhibitory effect of ginseng seeds on melanin production was verified to assess their potential as a skin depigmenting substance. Materials and Methods: The present study measured the inhibitory effect of ginseng seeds on melanin production through the tyrosinase inhibitory effect and analyzed their effects on melanin production in melan‑a‑cells. Results: Ethanol extract of ginseng seed was applied to melan‑a‑cells at a concentration of 100 ppm and melanin production was reduced by 35.1% without cytotoxicity. In addition, the ethanol extract of ginseng seed was shown to reduce tyrosinase activity. Conclusion: Because the results showed excellent melanin inhibitory activity compared with that obtained by arbutin, ethanol extracts of ginseng leaf and ginseng root at the same concentration, it can be concluded that ginseng seeds show great potential as a skin depigmenting substance.
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Lee, Y., Kim, K., Kim, S. S., Hur, J., Ha, S. K., & Cho, C. (2014). Inhibitory effects of ginseng seed on melanin biosynthesis. Pharmacognosy Magazine, , 272–275. https://doi.org/10.4103/0973-1296.133271