Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Antidiabetic Effect and Antioxidant Potential of Rosa canina Fruits

    Orhan N1, Aslan M1★, Hoşbaş S1, Deliorman Orhan D1★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Hipodrom-Ankara, Turkey.

    CORRESPONDENCE

    Aslan M

    Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Hipodrom-Ankara, Turkey.

    marslan@gazi.edu.tr

    Received: 11-05-2009; Accepted: 08-07-2009.

    phm-v5-i20 · pp. 309–315 · PUBLISHED 2009 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Rosa canina L. fruits (Rosaceae) are used to treat diabetes in Anatolia traditionally. In this study, the ethanol extract of R. canina fruits and its fractions were screened for their antioxidant, hypoglycaemic and antidiabetic activities. The ethanol extract that was administered for 7 days possessed a remarkable hypoglycemic effect at 250 mg/kg dose in streptozotocin (STZ) induced diabetic rats. Then it was fractionated through successive solvent extractions to yield CHCl3 Fr., EtOAc Fr., n-BuOH Fr. and R-H2O Fr. respectively. These fractions were administrated to normal plus glucose hyperglycemic rats. Additionally the subacute antidiabetic activities of the fractions were studied in diabetic rats for 7 days. The experimental data indicated that R-H2O Fr. possessed significant antidiabetic activity (50-62%) in diabetic rats. Also, a minor hypoglycemic effect was observed in normoglycemic plus glucose-hyperglycemic animals treated with R-H2O Fr. (15%). In vitro antioxidant experiments revealed that EtOAc Fr. showed the highest radical scavenging activity on DPPH (79.5±0.4%), whereas CHCl3 Fr. exhibited the maximum reducing power. The highest total phenolic content was observed in CHCl3 Fr. (18.5±0.6% gallic acid equivalent g/g fraction) but no correlation was observed between the antidiabetic activity of fractions and their phenolic contents. Our findings support the traditional usage of R. canina fruits as a folk remedy in the treatment of diabetes in Turkey.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      N, O., M, A., S, H., & D, D. O. (2009). Antidiabetic Effect and Antioxidant Potential of Rosa canina Fruits. Pharmacognosy Magazine, , 309–315.