Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    The effects of extraction method on recovery rutin from Calendula officinalis L. (Asteraceae)

    Frederico Severino Martins1★, Edemilson Cardoso da Conceição2, Elane Sousa Bandeira3, José Otávio Carréra Silva Junior3, Roseane Maria Ribeiro Costa3★ Corresponding author

    1. 1Departments of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
    2. 2Faculty of Pharmacy Research, Federal University of Goiás, Brazil.
    3. 3College of Pharmacy, Federal University of Para, Pará, Brazil.

    CORRESPONDENCE

    Frederico Severino Martins

    Departments of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.

    fsmfarmacia@hotmail.com

    Received: 05-02-2014; Revised: 27-03-2014.

    phm-v10-i39 · pp. 569–573 · PUBLISHED 2014 · DOI: 10.4103/0973-1296.139785

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Calendula officinalis L. (Asteraceae) is a Mediterranean specie, but in Europe and America it is cultivated for ornamental or medicinal purposes. This species is widely used for presenting activities, antiinflammatory antibacterial and antioxidant. However the therapeutic action is linked to the amount of assets of the extracted raw material. The extraction method of bioactive compounds is an important step in the manufacturing of herbal medicines, because secondary metabolites with therapeutic potential are usually found in small quantities in plant materials. Objective: Due the medical and commercial importance of C. officinalis, this study aimed to evaluate the impact of the extraction method on the quality of herbal extract and optimize the extraction of rutin from C. officinalis. Materials and Methods: The extraction of rutin was performed by ultrasound and shaker and the optimized conditions were determined by response surface methodology. Results: The results of ultrasound extraction assisted (UEA) and maceration dynamic (MD) showed that rutin yield ranged from 0.218 to 2.28% (w/w) when extract by ultrasound and 0.1-1.44% by MD. The optimal extraction condition for rutin (2.48% to UEA or 1.46% to MD) from C. officinalis by UEA or MD were a 19-22 min extraction, ethanol: water ratio of 35-40% and 0.05-0.056 mg/mL to raw material: solvent ratio. Conclusion: The UEA is more efficient to extraction rutin.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Martins, F. S., Conceição, E. C. D., Bandeira, E. S., Junior, J. O. C. S., & Costa, R. M. R. (2014). The effects of extraction method on recovery rutin from Calendula officinalis L. (Asteraceae). Pharmacognosy Magazine, , 569–573. https://doi.org/10.4103/0973-1296.139785