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    Article

    Element analysis and characteristic identification of non‑fumigated and sulfur‑fumigated Fritillaria thunbergii Miq. using microwave digestion‑inductively coupled plasma atomic emission spectrometry combined with Fourier transform infrared spectrometry

    Yajing Lou2,3, Hao Cai2,3,4★, Xiao Liu2,3,4, Sicong Tu5, Ke Pei2,3, Yingying Zhao2,3, Gang Cao3,4,6, Songlin Li7, Kunming Qin2,3, Baochang Cai2,3,4,6★ Corresponding author

    1. 1Department of Chinese Materia Medica, College of Pharmacy.
    2. 2Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, and.
    3. 3National First‑Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, PR China.
    4. 4Department of Medicine, University of New South Wales, Sydney, Australia.
    5. 5Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou.
    6. 6Department of Pharmaceutical Analysis and Metabolomics, Jiangsu Province Academy of Chinese Medicine, Nanjing, PR China, College of Pharmacy.

    CORRESPONDENCE

    Hao Cai

    Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, and.

    haocai_98@126.com

    Received: 01-04-2013; Revised: 28-04-2013.

    Volume 10, Issue 37s · pp. S30–S36 · PUBLISHED 21 February 2014 · DOI: 10.4103/0973-1296.127337

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Sulfur‑fumigation may induce chemical transformation of traditional Chinese medicines leading to harmful effects following patient ingestion. For quality control, it is urgently needed to develop a reliable and efficient method for sulfur‑fumigation identification. Materials and Methods: The spectrochemical identification of non‑fumigated and sulfur‑fumigated Fritillaria thunbergii Miq. was carried out to evaluate inorganic elements and organic components. The concentrations of 12 elements, including Zn, Mn, Cu, Fe, Li, Mg, Sr, Pb, As, Cd, Hg, and S of samples were determined by microwave digestion - inductively coupled plasma atomic emission spectrometry (ICP-AES). Meanwhile, Fourier transform infrared spectrometry (FTIR) was used for the study of chemical group characteristic reactions after sulfur-fumigation. Results: The concentrations of Fe, Mg, Hg, and S elements showed significant differences between non-fumigated and sulfur- fumigated Fritillaria thunbergii Miq. The characteristic stretching vibrations of some groups in FTIR spectra, such as -OH, -S = O and -S-O, provided the identification basis for the discrimination of non-fumigated and sulfur-fumigated Fritillaria thunbergii Miq. Conclusion: The application of microwave digestion ‑ ICP‑AES was successfully used in combination with FTIR to authenticate and evaluate the quality of medicinal Fritillaria thunbergii Miq. Further applications of this technique should be explored.

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      Lou, Y., Cai, H., Liu, X., Tu, S., Pei, K., Zhao, Y., Cao, G., Li, S., Qin, K., & Cai, B. (2014). Element analysis and characteristic identification of non‑fumigated and sulfur‑fumigated Fritillaria thunbergii Miq. using microwave digestion‑inductively coupled plasma atomic emission spectrometry combined with Fourier transform infrared spectrometry. Pharmacognosy Magazine, 10(37s), S30–S36. https://doi.org/10.4103/0973-1296.127337