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    Article

    Antiasthmatic effects of schizandrae fructus extract in mice with asthma

    Hyungwoo Kim2, Yong‑Tae Ahn3, Youn Sook Kim4, Su In Cho5, Won Gun An5★★ Corresponding author

    1. 1Associate Professor.
    2. 2Department of Biomedical Science, Kyungdong University, Goseong‑gun, Gangwon‑do, South Korea.
    3. 3Master of Science.
    4. 4Professor, School of Korean Medicine, Pusan National University, Pusan.

    CORRESPONDENCE

    Won Gun An

    wgan@pusan.ac.kr

    Received: 25-04-2013; Revised: 01-05-2013.

    Volume 10, Issue 37s · pp. S80–S85 · PUBLISHED 21 February 2014 · DOI: 10.4103/0973-1296.127348

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Schizandrae fructus (SF), the fruit of Schisandra chinensis, has been used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular disease, and as a tonic and astringent in China, Japan, and Korea. Objective: Investigation of the antiasthmatic effects of SF. Materials and Methods: We investigated the effects of SF on airway hyperresponsiveness (AHR) to methacholine, production levels of antigen‑specific antibodies, and histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma induced by repeated intranasal instillation of an antigen. Results: SF lowered AHR to methacholine (P < 0.05), antigen‑specific immunoglobulin E (IgE) level (P < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 0.01) levels, and immune cell infiltration. SF and PD did not affect the levels of antigen‑specific IgG1 and IgG2a antibodies. Conclusion: Our data suggest that SF has possible application as an antiasthmatic drug. We also suggest that SF could be used as a complementary or alternative medicine to glucocorticoids.

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      Kim, H., Ahn, Y., Kim, Y. S., Cho, S. I., & An, W. G. (2014). Antiasthmatic effects of schizandrae fructus extract in mice with asthma. Pharmacognosy Magazine, 10(37s), S80–S85. https://doi.org/10.4103/0973-1296.127348