Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Pretreatment with Assafoetida exerts dose-dependent dual effects on rat hearts

    Mansour Esmailidehaj1★, Mohadeseh Kakoo1, Mohammad Ebrahim Rezvani1, Mohammad Hossein Mosaddeghmehrjardi2★ Corresponding author

    1. 1Departments of Physiology, University of Medical Sciences, Yazd, Iran.
    2. 2Pharmacology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

    CORRESPONDENCE

    Mansour Esmailidehaj

    Departments of Physiology, University of Medical Sciences, Yazd, Iran.

    ned1382@gmail.com

    Received: 05-12-2012; Revised: 19-01-2013.

    Volume 10, Issue 38 · pp. 147–153 · PUBLISHED 17 April 2014 · DOI: 10.4103/0973-1296.131026

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Context: Although many studies displayed the favorable effects of Assafoetida, some of them reported that high doses of Assafoetida could lead to harmful effects. Aims: In this study, the effect of pretreatment with Assafoetida investigated on ischemic–reperfusion injury in isolated rat heart model. Materials and Methods: Thirty two male Wistar rats were divided into 4 groups of eight. Group 1 as the control (Con) group and three other groups as the treatment groups that given Assafoetida by gavage at levels of 25, 50 and 100 mg/kg, once a day for four weeks (T25, T50 and T100 groups). Then their hearts were subjected to 30 min global ischemia and 90 min reperfusion under langendorff apparatus. Results: The data shown that hemodynamic parameters including left ventricular developed pressure (LVDP) and maximum and minimum of pressure changes (±dp/dt) were increased in T25 and decreased in T50 and T100 groups during reperfusion in comparison with Con group. There was not any signifi cant difference in the incidence of irreversible ventricular fi brillation between T25 and Con group, while it was increased in T50 and T100 groups signifi cantly. There was not any signifi cant difference in infarct size between all groups. Conclusion: These data indicate that pretreatment of rats with Assafoetida have cardioprotective effects in low doses and cardiotoxic effects in higher doses. Therefore, it needs more investigation in the future.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Esmailidehaj, M., Kakoo, M., Rezvani, M. E., & Mosaddeghmehrjardi, M. H. (2014). Pretreatment with Assafoetida exerts dose-dependent dual effects on rat hearts. Pharmacognosy Magazine, 10(38), 147–153. https://doi.org/10.4103/0973-1296.131026