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    Article

    Antinociceptive effect of Encholirium spectabile: A Bromeliaceae from the Brazilian caatinga biome

    Sarah Raquel Gomes de Lima-Saraiva1, Juliane Cabral Silva2, Carla Rodrigues Cardoso Branco3, Alexsandro Branco1, Elba Lúcia Cavalcanti Amorim1, Jackson Roberto Guedes da Silva Almeida2★★ Corresponding author

    1. 1Department of Pharmacy, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
    2. 2Nucleus of Study and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil.
    3. 3State University of Feira de Santana, Laboratory of Phytochemistry, Feira de Santana, Bahia, Brazil.

    CORRESPONDENCE

    Jackson Roberto Guedes da Silva Almeida

    Nucleus of Study and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil.

    jackson.guedes@univasf.edu.br

    Received: 20-05-2012; Revised: 25-06-2012.

    Volume 10, Issue 39s · pp. 655–660 · PUBLISHED 2014 · DOI: 10.4103/0973-1296.139817

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Encholirium spectabile is a species found in outcrops rocky throughout the Brazilian Caatinga. Objective: This study was carried out to evaluate the antinociceptive effects of ethanolic extract of the leaves from E. spectabile (Es-EtOH) in mice using chemical and thermal models of nociception. Material and Methods: HPLC was used to determine the fingerprint chromatogram. The Es-EtOH was examined for its antinociceptive activity at the doses of 100, 200 and 400 mg/ kg intraperitoneal (i.p.). The evaluation of antinociceptive activity was carried out by the acetic acid- induced writhing, formalin and hot plate tests in mice. Rota-rod test was used for the evaluation of motor coordination. Results: In the acetic acid-induced writhing test, the Es-EtOH (100, 200 and 400 mg/kg, i.p.) reduced the number of writhings by 68.59, 79.33 and 65.28%, respectively. Additionally, Es-EtOH (100, 200 and 400 mg/kg, i.p.) decreased by 34.14, 52.61 and 60.97% the paw licking time in the first phase, as well as 89.56, 79.90 and 96.71% in the second phase of the formalin test, respectively. Es-EtOH also showed effect in the hot plate test, since increased the latency time at dose of 100 mg/kg after 60 minutes. In addition, Es-EtOH did not impair motor coordination. The presence of phenolic compounds in the extract was confirmed using HPLC. These results indicate that Es-EtOH has antinociceptive activity, probably of peripheral origin. The mechanism involved is not completely understood but, at least in part there is the participation of opioid receptors.

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      Lima-Saraiva, S. R. G. D., Silva, J. C., Branco, C. R. C., Branco, A., Amorim, E. L. C., & Almeida, J. R. G. D. S. (2014). Antinociceptive effect of Encholirium spectabile: A Bromeliaceae from the Brazilian caatinga biome. Pharmacognosy Magazine, 10(39s), 655–660. https://doi.org/10.4103/0973-1296.139817