Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Hepatoprotective and in vivo antioxidant activity of Olax subscorpioidea Oliv. (Olacaceae) and Distemonathus benthamianus Baill. (Caesalpiniaceae)

    Kouassi Konan1★, N’dah Kouamé Justin2, Boyvin Lydie3, Méité Souleymane3, Yapo Adou Francis1★ Corresponding author

    1. 1N’guessan Jean David Department of Biochemistry and Microbiology, Laboratory of Biochemical Pharmacodynamy.
    2. 2Department of Anatomy, Pathological Anatomy Cytology, Histology-Embryology and Cytogenetics, Laboratory of pathological anatomy, Félix Houphouët-Boigny University of Abidjan, 22 BP 582 Abidjan 22, Côte d’Ivoire.
    3. 3Department of Clinical and Fundamental Biochemistry, Pasteur Institute of Côte d’Ivoire, 01 BP 490 Abidjan 01 , Republic of Côte d'Ivoire.

    CORRESPONDENCE

    Kouassi Konan

    N’guessan Jean David Department of Biochemistry and Microbiology, Laboratory of Biochemical Pharmacodynamy.

    nguessanjd@yahoo.fr

    Received: 14-04-2014; Revised: 27-05-2014.

    Volume 11, Issue 41 · pp. 111–116 · PUBLISHED 21 January 2015 · DOI: 10.4103/0973-1296.149723

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Liver diseases are on rise and remain a serious health problem. Olax subscorpioidea and Distemonanthus benthamianus are two plants used in Ivorian traditional medicine in the treatment of many diseases including jaundice and hepatitis. Objective: The present study was carried out to assess the hepatoprotective and in vivo antioxidant potentials of the hydro‑ethanolic leaf extracts of these plants in carbon tetrachloride (CCl4)‑induced hepatotoxicity in rats. Materials and Methods: The plant extracts at doses of 25 and 100 mg/kg bw, and silymarin (25 mg/kg bw) were intraperitoneally (i.p.) injected once daily for 7 days to different groups of rats. Hepatotoxicity was induced on the 7th day in all the group animals except control. Rats were sacrificed on the 8th day and blood was collected. Serum biochemical parameters and antioxidant activity were measured using standard procedures. Histopathological examinations of liver rats were also performed. Results and Discussion: Hepatotoxicity induced with CCl4 was well manifested by significant increase in serum activities of GOT, GPT, ALP and GGT, and enhancement of total bilirubin and TBARS levels. On the other hand, the level of total protein, albumin, α1‑globulin significantly decreased, and DPPH‑free radical scavenging activity and TAP were lowered. Pretreatment with plant extracts and silymarin prevent the toxic effects of CCl4 by decreasing serum enzyme activities, total bilirubin and TBARS levels and improving serum TAP and DPPH‑free radical scavenging potential. Histopathological observations showed almost normal hepatic cells with a mild degree of inflammation, lesser fatty infiltration and absence of necrosis among the rats treated at 100 mg/kg of extracts of both the plants. Conclusion: The results suggest that the hydro‑ethanolic leaf extracts of O. subscorpioidea and D. benthamianus possesses hepatoprotective and in vivo antioxidant activity.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Konan, K., Justin, N. K., Lydie, B., Souleymane, M., & Francis, Y. A. (2015). Hepatoprotective and in vivo antioxidant activity of Olax subscorpioidea Oliv. (Olacaceae) and Distemonathus benthamianus Baill. (Caesalpiniaceae). Pharmacognosy Magazine, 11(41), 111–116. https://doi.org/10.4103/0973-1296.149723