Obtainment of pellets using the standardized liquid extract of Brosimum gaudichaudii Trécul (Moraceae)
Omar Paulino Silva Filho1★, Leandra Almeida Ribeiro Oliveira1, Frederico Severino Martins2, Leonardo Luiz Borges1, Osvaldo de Freitas2, Edemilson Cardoso da Conceição1★ Corresponding author
- 1Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil.
- 2Laboratory of Research, Development and Pharmacotechnical, Faculty of Pharmaceutical Science from Ribeirão Preto, University of São Paulo, Brazil.
CORRESPONDENCE
Omar Paulino Silva Filho
Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil.
Received: 19-12-2013; Revised: 25-04-2014.
Volume 11, Issue 41 · pp. 170–175 · PUBLISHED 21 January 2015 · DOI: 10.4103/0973-1296.149734
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ABSTRACT
Background: The standardized liquid extract of Brosimum gaudichaudii Trécul is an alternative for the treatment of vitiligo. There is a shortage of solid oral dosage forms developed from standardized extracts of this plant specie. Objective: This study is aimed to obtain pellets with a standardized liquid extract of B. gaudichaudii. Results: The standardized liquid extract of B. gaudichaudii was obtained through maceration and percolation with a 55% ethanol‑water solution (v/v). Pellets were obtained through a mixture of extract of 500 g of B. gaudichaudii standardized extract, 500 g of microcrystalline cellulose PH101 and 10 g of hydroxypropyl methylcellulose K100. The pellets obtained presented a homogeneity yield of 92%, aspect ratio of 1.16 ± 0.65, shape fator eR of 0.35 ± 0.09 and Feret diammeter of 0.87 ± 0.27. These pellets were coated with a suspension composed of titanium dioxide, aluminum red lacquer, ethyl cellulose, talc and magnesium stearate. Before the photostability test, the uncoated pellets showed psoralen content equal to 0.13 ± 0.01% and to the 5‑MOP was 1.40 ± 0.27%. After exposure to one level (3 J.cm‑2) of UVB irradiation the uncoated pellets presented a degradation of 2.16% of psoralen and 8.1% of 5‑MOP. After exposure to three levels (10, 20 and 30 J.cm‑2) of UVA irradiation the uncoated pellets exhibited photodegradation of 9.78, 17.64, 24.21% of psoralen and 18.95, 23.68, 28.48% for 5‑MOP. The coated pellets where unaffected after photostability test. Conclusion: Pellets were obtained with the standardized liquid extract of B. gaudichaudii and coating is a technological alternative to ensure the stability of the formula.
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Filho, O. P. S., Oliveira, L. A. R., Martins, F. S., Borges, L. L., Freitas, O. D., & Conceição, E. C. D. (2015). Obtainment of pellets using the standardized liquid extract of Brosimum gaudichaudii Trécul (Moraceae). Pharmacognosy Magazine, 11(41), 170–175. https://doi.org/10.4103/0973-1296.149734