Identification of longevity, fertility and growth‑promoting properties of pomegranate in Caenorhabditis elegans
Hasan Kılıçgün1★, Nazlı Arda2, Evren Önay Uçar2★ Corresponding author
- 1Department of Nutrition and Dietetic, School of Health, Erzincan University, 24100, Erzincan, Turkey.
- 2Department of Molecular Biology and Genetics, İstanbul University Faculty of Science, İstanbul, Turkey.
CORRESPONDENCE
Hasan Kılıçgün
Department of Nutrition and Dietetic, School of Health, Erzincan University, 24100, Erzincan, Turkey.
Received: 02-11-2013; Revised: 12-09-2014.
Volume 11, Issue 42 · pp. 356–359 · PUBLISHED 12 March 2015 · DOI: 10.4103/0973-1296.153089
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ABSTRACT
Background: Pomegranate (Punica granatum L.) is commonly consumed as fresh fruit and fruit juice. It is also used in the production of jam, wine, food coloring agent, and flavor enhancer. Objective: The aim of this study was to identify the possible longevity, fertility and growth promoting properties of different ethanolic extract concentrations of pomegranate in Caenorhabditis elegans, which is increasingly popular and has proven to be a very useful experimental model organism for aging studies as well as for testing antioxidants and other compounds for effects on longevity. Materials and Methods: In this study, five experimental groups (20, 10, 5, 2.5 and 1.25 mg pomegranate extract/mL and one control group) were used to determine the most effective dose of pomegranate in terms of longevity, fertility and growth parameters. Results: It was seen that, pomegranate extracts up to the concentration of 5 mg/mL, had the potential to promote for the longevity, formation of new generations, fertility of new generations and growth properties of C. elegans although higher concentrations significantly reduced these parameters. Conclusion: these findings indicated that pomegranate could be used as a supplement to enhance longevity, fertility and growth rate for the other living organisms and human beings, but the dose should be carefully adjusted to avoid adverse effects.
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Kılıçgün, H., Arda, N., & Uçar, E. Ö. (2015). Identification of longevity, fertility and growth‑promoting properties of pomegranate in Caenorhabditis elegans. Pharmacognosy Magazine, 11(42), 356–359. https://doi.org/10.4103/0973-1296.153089