Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Effect of co-administration of Angelicae gigantis radix and Lithospermi radix on rat hepatic injury induced by carbon tetrachloride

    Chi-Yeon Lim1, Bu-Yeo Kim2, Se-Hyun Lim3, Su-In Cho4★★ Corresponding author

    1. 1Department of Medicine, College of Medicine, Dongguk University, Ilsan.
    2. 2Department of Medical Research, Korea Institute of Oriental Medicine, Daejon 305-701, Republic of Korea.
    3. 3Department of Nursing, School of Public Health, Far East University, Chungbuk 369-700, Republic of Korea.
    4. 4Department of Korean Medicine, School of Korean Medicine, Pusan National University, Busan 626-870, Republic of Korea.

    CORRESPONDENCE

    Su-In Cho

    Department of Korean Medicine, School of Korean Medicine, Pusan National University, Busan 626-870, Republic of Korea.

    sicho@pusan.ac.kr

    Received: 08-04-2014; Revised: 27-05-2014; Accepted: 12-03-2015.

    Volume 11, Issue 42 · pp. 395–395 · PUBLISHED 12 March 2015 · DOI: 10.4103/0973-1296.153095

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Co‑administration of Angelicae gigantis radix (AGR) and Lithospermi radix (LR) has been commonly applied to patients to treat cardiac and hepatic disorders. Individual bioactivities of these herbal medicines have been widely investigated, but the hepatoprotective effects of co‑treatment of AGR and LR have yet to be clarified. Objective: The present study investigated the protective effects of extracts of AGR and LR on carbon tetrachloride (CCl4) induced hepatic injury. Materials and Methods: In this study, we measured the hepatoprotective activity of individual and co‑treatment of the two herbal medicines on hepatic injury induced by CCl4 by measuring different biochemical parameters such as serum aspartate aminotransaminase (AST) and serum alanine aminotransaminase (ALT). Microarray technology also used to compare ontological difference with individual and co‑treatment of these two. Results: Combined treatment with AGR and LR (AGR + LR) decreased AST and ALT level in serum which demonstrate hepatoprotective effect of the therapy. When the effect of AGR and LR according to treatment conditions was measured, co‑treatment showed the most prominent effect on hepatic injury by CCl4 rather than individual treatment condition. We further defined gene set that could be the molecular target of herbal effect on hepatic injury by CCl4 using bioinformatical analysis of interaction network. Highly recovered genes by treating AGR + LR play significant roles in response to hepatic injury induced by CCl4. Conclusion: Combined treatment with AGR and LR showed synergistic protective effects on the CCl4‑induced rat hepatic tissue injury.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Lim, C., Kim, B., Lim, S., & Cho, S. (2015). Effect of co-administration of Angelicae gigantis radix and Lithospermi radix on rat hepatic injury induced by carbon tetrachloride. Pharmacognosy Magazine, 11(42), 395–395. https://doi.org/10.4103/0973-1296.153095