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    Article

    Optimization of ultrasound‑assisted extraction of phenolic compounds from Cimicifugae rhizoma with response surface methodology

    Lin Liu2, Bao-Jia Shen3,4,5, Dong-Hao Xie2★, Bao-Chang Cai3,4,5★, Kun-Ming Qin3,4,5, Hao Cai3,5★ Corresponding author

    1. 1Department of Pharmacy, Dahua Hospital, Xuhui District, Shanghai 200237, China.
    2. 2Engineering Research Center of Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China.
    3. 3Nanjing Haichang Chinese Medicine Group Co. Ltd, Nanjing 210061, China.
    4. 4Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, Nanjing 210023, PR, China.

    CORRESPONDENCE

    Dong-Hao Xie

    Engineering Research Center of Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China.

    bc_cai@163.com

    Received: 14-10-2013; Revised: 12-12-2013.

    Volume 11, Issue 44 · pp. 682–689 · PUBLISHED 16 September 2015 · DOI: 10.4103/0973-1296.165545

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Cimicifugae rhizoma was a Ranunculaceae herb belonging to the composite family, and the roots of C. rhizoma have been widely used in tradition Chinese medicine. Materials and Methods: Ultrasound‑assisted extraction (UAE) of phenolic compounds from C. rhizoma. Caffeic acid (CA), isoferulic acid (IA), ferulic acid (FA), and total phenols were quantified by high‑performance liquid chromatography‑diode array detection and ultraviolet‑visible spectrophotometer. Effects of several experimental parameters, such as ultrasonic power (W), extraction temperature (°C), and ethanol concentration (%) on extraction efficiencies of phenolic compounds from C. rhizoma were evaluated. Results: The results showed that the optimal UAE condition was obtained with ultrasonic power of 377.35 W, extraction temperature of 70°C, and ethanol concentration of 58.37% for total phenols, and ultrasonic power of 318.28 W, extraction temperature of 59.65°C, and ethanol concentration of 64.43% for combination of CA, IA, FA. Conclusions: The experimental values under optimal conditions were in good consistent with the predicted values, which suggested UAE is more efficient for the extraction of phenolic compounds from plant materials.

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      Liu, L., Shen, B., Xie, D., Cai, B., Qin, K., & Cai, H. (2015). Optimization of ultrasound‑assisted extraction of phenolic compounds from Cimicifugae rhizoma with response surface methodology. Pharmacognosy Magazine, 11(44), 682–689. https://doi.org/10.4103/0973-1296.165545