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    Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors

    Ruizhi Men2,3, Ning Li2,3★, Chihong Ding4, Yingzhan Tang2,3, Yachao Xing2,3, Wanjing Ding4, Zhongjun Ma4★ Corresponding author

    1. 1School of Traditional Chinese Materia Medica, China.
    2. 2Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
    3. 3Institute of Marine Biology, Ocean College, Zhejiang University, Zijingang Campus, No. 866 Yuhangtang Road, Hangzhou 310058, PR, China.

    CORRESPONDENCE

    Ning Li

    Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.

    liningsypharm@163.com

    Received: 24-05-2015; Revised: 14-07-2015.

    Volume 12, Issue 46s · pp. S231–S236 · PUBLISHED 11 May 2016 · DOI: 10.4103/0973-1296.182153

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China. Materials and Methods: To reveal the functional material basis, we performed bioactivity‑guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. Results: It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β‑unsaturated ketone moiety). Furthermore, bioactivity‑guided phytochemical research led eight compounds (1–8), which were elucidated as 3‑isopropyl‑5‑acetoxycyclohexene‑2‑one‑1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol‑3‑O‑β‑D‑glucopyranoside (7) and 5α‑6β‑dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively.

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      Men, R., Li, N., Ding, C., Tang, Y., Xing, Y., Ding, W., & Ma, Z. (2016). Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors. Pharmacognosy Magazine, 12(46s), S231–S236. https://doi.org/10.4103/0973-1296.182153