Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Evaluation of Herb–Drug Interactions of Hovenia dulcis Fruit Extracts

    Jong Suk Park1, Shaheed Ur Rehman1, In Sook Kim1, Min Sun Choi1, Chun-Soo Na2, Hye Hyun Yoo1★★ Corresponding author

    1. 1Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.
    2. 2Lifetree Biotech Co., Ltd., Suwon, Gyeonggi-do, Republic of Korea.

    CORRESPONDENCE

    Hye Hyun Yoo

    Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.

    yoohh@hanyang.ac.kr

    Received: 08-04-2016; Revised: 19-05-2016; Accepted: 18-04-2017.

    Volume 13, Issue 50 · pp. 236–239 · PUBLISHED 18 April 2017 · DOI: 10.4103/0973-1296.204552

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Hovenia dulcis (Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including H. dulcis fruit extracts, to be taken with prescription drugs. Objective: In this study, possible food–drug interactions involving H. dulcis fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity. Material and Methods: The water extract of H. dulcis fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry. Results: H. dulcis fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested. Conclusion: This result suggests that H. dulcis fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Park, J. S., Rehman, S. U., Kim, I. S., Choi, M. S., Na, C., & Yoo, H. H. (2017). Evaluation of Herb–Drug Interactions of Hovenia dulcis Fruit Extracts. Pharmacognosy Magazine, 13(50), 236–239. https://doi.org/10.4103/0973-1296.204552