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    Protective Effect of Pluchea lanceolata against Aluminum Chloride-induced Neurotoxicity in Swiss Albino Mice

    Ravi Mundugaru1, Senthilkumar Sivanesan1★, Padmaja Udaykumar2, Niranjan Rao3, Naveen Chandra4★ Corresponding author

    1. 1Department of Research and Development, Saveetha University, Chennai, Tamil Nadu, India.
    2. 2Department of Pharmacology, Father Muller Medical College, Mangalore, Karnataka, India.
    3. 3Department of PG Studies in Panchakarma, S.D.M. College of Ayurveda, Kuthpady, Udupi, India.
    4. 4Departments of Pharmacology and Biochemistry, S.D.M. Centre for Research in Ayurveda and Allied Sciences, Udupi, India.

    CORRESPONDENCE

    Senthilkumar Sivanesan

    Department of Research and Development, Saveetha University, Chennai, Tamil Nadu, India.

    senbio@gmail.com

    Received: 07-04-2017; Revised: 17-05-2017; Accepted: 17-05-2017.

    Volume 13, Issue 51s · pp. S567–72 · PUBLISHED 11 October 2017 · DOI: 10.4103/pm.pm_124_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Aluminum chloride (AlCl3) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in the brain. The herb Pluchea lanceolata is commonly known as “Rasana” and used as a nerve tonic in neuroinflammatory conditions in Indian system of medicine. Objective: To evaluate the neuroprotective activity of hydroalcoholic extract of P. lanceolata in chronic AlCl3-induced neurotoxicity in Swiss albino mice. Materials and Methods: Albino mice were categorized into four different groups; Group 1served as vehicle control, Group 2 mice were administered with AlCl3, 40 mg/kg body weight by intraperitoneal route for 45 consecutive days. Groups 3 and 4 mice were administered with AlCl3, 40 mg/kg body weight intraperitoneal for 45 consecutive days along with hydroalcoholic extract of P. lanceolata at 200 and 400 mg/kg body weight. Results: Chronic administration of AlCl3 resulted in behavioral deficits, triggered lipid peroxidation, increased acetylcholinesterase (AChE) activity, and histological alterations. Co-administration of hydroalcoholic extract of P. lanceolata attenuated many of the AlCl3-induced alterations such as behavioral, lipid peroxidation, AChE, and histological changes of brain tissue. Conclusion: The results of the present study have demonstrated the protective role of hydroalcoholic extract of P. lanceolata against AlCl3-induced neurotoxicity in Swiss albino mice. The neuroprotective efficacy of P. lanceolata can help reduce the symptoms caused by toxic protein aggregates in several degenerative diseases.

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      Mundugaru, R., Sivanesan, S., Udaykumar, P., Rao, N., & Chandra, N. (2017). Protective Effect of Pluchea lanceolata against Aluminum Chloride-induced Neurotoxicity in Swiss Albino Mice. Pharmacognosy Magazine, 13(51s), S567–72. https://doi.org/10.4103/pm.pm_124_17