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    The Natural Compound Dansameum Reduces foam Cell Formation by Downregulating CD36 and Peroxisome Proliferator‑activated Receptor‑gamma; Expression

    Kang-Seo Park1★, Sang Hyun Ahn1★, Kang Pa Lee1★, Sun-Young Park5, Jin Hong Cheon6, Jun-Yong Choi7, Kibong Kim6,8★★ Corresponding author

    1. 1Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Departments of.
    2. 2Anatomy and.
    3. 3Department of Medical Science, School of Medicine, Konkuk University, Seoul, Departments of, Republic of Korea.
    4. 4Physiology, College of Korean Medicine, Semyung University, Jecheon-si, Chungcheongbuk-do.
    5. 5Korean Pediatrics and.
    6. 6Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do.
    7. 7Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

    CORRESPONDENCE

    Kang-Seo Park

    Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Departments of.

    kkb2630@gmail.com

    Received: 16-03-2017; Revised: 13-06-2017.

    Volume 13, Issue 52s · pp. S868–S874 · PUBLISHED 31 January 2018 · DOI: 10.4103/pm.pm_112_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Atherosclerosis‑induced vascular disorders are major causes of death in most western countries. During the development of atherosclerotic lesions, foam cell formation is essential and formed through the expression of CD36 and the peroxisome proliferator‑activated receptor gamma (PPAR‑γ). Objective: To investigate whether dansameum extract (DSE) could show anti‑atherosclerotic effect through down‑regulating cellular redox state including CD36 and PARP‑γ expression in oxidative low‑density lipoprotein (oxLDL)‑treated RAW264.7 cells and on differentiated foam cells in ApoE Knockout (ApoE‑/‑) mice. Materials and Methods: The Korean polyherbal medicine DSE was prepared from three plants in the following proportions: 40 g of Salvia miltiorrhiza root, 4 g of Amomumxanthioides fruit, and 4 g of Santalum album lignum. The immunohistochemistry and reverse transcription‑polymerase chain reaction was used for analysis of protein and mRNA involved in foam cell formation. Results: We first showed that effects of DSE on foam cell formation in both oxLDL‑induced RAW264.7 cells and in blood vessels from apolipoprotein E deficientApoE‑/‑ mice with high fat diet‑fed. DSE treatment significantly reduced the expression of CD36 and PPAR‑γ in oxLDL‑stimulated RAW264.7 cells and ApoE‑/‑mice, in the latter case by regulating heme oxygenase‑1. Furthermore, DSE treatment also reduced cellular lipid content in vitro and in vivo experiments. Conclusion: Our data suggest that DSE may have anti‑atherosclerotic properties through regulating foam cell formation.

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      Park, K., Ahn, S. H., Lee, K. P., Park, S., Cheon, J. H., Choi, J., & Kim, K. (2018). The Natural Compound Dansameum Reduces foam Cell Formation by Downregulating CD36 and Peroxisome Proliferator‑activated Receptor‑gamma; Expression. Pharmacognosy Magazine, 13(52s), S868–S874. https://doi.org/10.4103/pm.pm_112_17