Alleviation of Doxorubicin‑induced Hepatic Toxicity with Fermented Cordyceps sinensis via Regulating Hepatic Energy Metabolism in Rats
Ping‑An Yao1, Rong Wu1, Yao‑Li Zhang2, Xiao‑Hua Cui1, Ke‑Zhao Wei1, Xu Xu2, Jian‑Ping Gao1★★ Corresponding author
- 1Department of Pharmacology, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, China.
- 2Department of Chemistry, School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China.
CORRESPONDENCE
Jian‑Ping Gao
Department of Pharmacology, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, China.
Received: 10-08-2017; Revised: 04-02-2018.
Volume 14, Issue 56 · pp. 283–289 · PUBLISHED 14 August 2018 · DOI: 10.4103/pm.pm_354_17
View on Pharmacogn. Mag. original site ↗
ABSTRACT
Background: Cordyceps sinensis (CS), a traditional Chinese herbal medicine, has many pharmacological effects. Doxorubicin (DOX) is a spectrum antitumor drug, but it has toxicity to multiple organs. Objective: The objective of this study was to evaluate the effect of fermented CS on regulating hepatic energy metabolism against DOX‑treated hepatic toxicity in rats. Materials and Methods: Male Sprague‑Dawley rats were randomly divided into six groups and administrated orally for 23 days as follows: normal control group, CS (1.50 g/kg/d) control group, DOX control group, and DOX + CS (0.75 g/kg/d, 1.5 g/kg/d, 3.00 g/kg/d) groups. Rats in DOX‑treated groups were intraperitoneally injected with DOX at a dose of 2.5 mg/kg at every 48 h, and repeated for six times. At the end of the experiment, the mortality and liver index, blood biomarkers about the hepatic injury, hepatic histopathological changes, hepatic energy metabolism, and hepatic cyclic adenosine monophosphate (AMP) were measured. Results: DOX‑induced a higher mortality, the damage of the liver manifests itself in the increase of liver weight index and the activity of serum aspartate aminotransferase, the decrease of serum contents of total protein and albumin, and histopathological changes, and the disorders of energy metabolism including the decrease of phosphocreatine, adenosine‑triphosphate, adenosine diphosphate, AMP, and total adenine nucleotides in hepatic tissues. Fermented CS not only could attenuate those changes but also could increase the content of hepatic cAMP. Conclusion: DOX induces hepatic injury accompanying hepatic energy metabolism disorders. Fermented CS regulates the disorders of hepatic energy metabolism, thereby attenuating liver injury caused by DOX.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Yao, P., Wu, R., Zhang, Y., Cui, X., Wei, K., Xu, X., & Gao, J. (2018). Alleviation of Doxorubicin‑induced Hepatic Toxicity with Fermented Cordyceps sinensis via Regulating Hepatic Energy Metabolism in Rats. Pharmacognosy Magazine, 14(56), 283–289. https://doi.org/10.4103/pm.pm_354_17