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    Article

    Formulation and Evaluation of Wound Healing Activity of Sophorolipid-Sericin Gel in Wistar Rats

    Snehal V. More2★, Santosh S. Koratkar3, Navnath Kadam4, Sachin Agawane2, Asmita Prabhune2★ Corresponding author

    1. 1Division of Biochemical Sciences, CSIR-National Chemical Laboratory, India.
    2. 2Division of Biochemical Sciences, Symbiosis School of Biological Sciences, Symbiosis International University, India.
    3. 3Department of Quality Assurance Techniques, Poona College of Pharmacy, Pune, Maharashtra, India.

    CORRESPONDENCE

    Snehal V. More

    Division of Biochemical Sciences, Symbiosis School of Biological Sciences, Symbiosis International University, India.

    sv.more@ncl.res.in

    Received: 18-07-2018; Revised: 02-11-2018.

    Volume 15, Issue 62s · pp. S123–S127 · PUBLISHED 26 April 2019 · DOI: 10.4103/pm.pm_392_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Sericin is a useful by‑product of silk processing and is resistant to oxidation and ultraviolet and can absorb and release moisture easily. Sericin has biological activities such as antibacterial, antioxidant, and tyrosinase inhibition. Sophorolipids are microbial extracellular glycolipids produced by resting cells of Candida bombicola. Sophorolipids show excellent skin compatibility and also have antibacterial property. In this study, we have developed a novel formulation consisting of sericin and sophorolipid with calcium alginate as a binding agent. Since both the ingredients are biocompatible and biodegradable, the formulation was tested for wound healing in Wistar rats. A commercial ointment povidone was used as control. The animal group, treated with sericin and sophorolipid cream, showed fast contraction, rapid closure, and healing when compared with control and commercial ointment. These observations were validated with histopathological studies where more fibroblast proliferation, angiogenesis, and keratinization were observed. This is a green, cost‑effective formulation for fast wound healing.

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      More, S. V., Koratkar, S. S., Kadam, N., Agawane, S., & Prabhune, A. (2019). Formulation and Evaluation of Wound Healing Activity of Sophorolipid-Sericin Gel in Wistar Rats. Pharmacognosy Magazine, 15(62s), S123–S127. https://doi.org/10.4103/pm.pm_392_18