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    The Effects of Elateriospermum tapos against Obese Maternal Rat in Mitigating Obesity Development among their Adult Female Offspring

    Hasnah Bahari2★, Azrina Zainal Abidin2,3, Santhra Segaran Balan2,3, Kokila Vani Perumal2, Nurain Syahirah Rosli3, Amalia Hazirah Ahamad Lotafi3, Sharmmila Danabala3, Malarmugila Manimaran3, Nurul Husna Shafie4, Maizaton Atmadini Abdullah5, Azmiza Syawani Jasni6★ Corresponding author

    1. 1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia.
    2. 2Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, Departments of, Malaysia.
    3. 3Nutrition and Dietetics, Malaysia.
    4. 4Pathology and, Malaysia.
    5. 5Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia.

    CORRESPONDENCE

    Hasnah Bahari

    Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, Departments of, Malaysia.

    haba@upm.edu.my

    Received: 17-04-2020; Revised: 29-05-2020; Accepted: 19-08-2020.

    Volume 16, Issue 72 · pp. 706–712 · PUBLISHED 16 February 2021 · DOI: 10.4103/pm.pm_142_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: This study was aim to investigate the effect of E. tapos supplementation in obese rat prior pregnancy on the female offspring’s body weight, liver and kidney profile, and histological changes of heart, liver, kidney, and retroperitoneal white adipose tissue (RpWAT). Materials and Methods: Thirty female Sprague Dawley rats were used in this study. Six rats were assigned to dams normal diet group fed with standard chow diet. The remaining rats were fed with high‑fat and cafeteria diet (HFCD) to generate obesity for 5 weeks. The obese rats were further divided into 4 groups; group1; Dams Negative Control (DNC, normal saline only), group 2; Dams Positive Control (DPC, Orlistat drug 200mg/kg), Dams Treatment 1 (DTX1, E. tapos seed 200 mg/ kg) and Dams Treatment 2 (DTX2, E. tapos shell 200mg/kg) extracts for 6 weeks daily prior to mating. The weaning offspring were then designated into 6 groups according to their dam’s group (n = 6/group). The offspring were culled at 12th week of age in order to have their blood sample and organs. Results: Adult offspring from DTX2 group showed a decrease in weight gain, alanine aminotransferase, and creatinine level compared to adult offspring from DNC. Histological examination showed that liver and RpWAT of offspring from DTX1 and DTX2 groups were comparable with normal diet group, indicating that the extracts were capable in reversing the high fat diet effect to the organ. Conclusion: E. tapos shell supplementation was effective in reducing the development of obesity with no harmful effect among adult female rat offspring.

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      Bahari, H., Abidin, A. Z., Balan, S. S., Perumal, K. V., Rosli, N. S., Lotafi, A. H. A., Danabala, S., Manimaran, M., Shafie, N. H., Abdullah, M. A., & Jasni, A. S. (2021). The Effects of Elateriospermum tapos against Obese Maternal Rat in Mitigating Obesity Development among their Adult Female Offspring. Pharmacognosy Magazine, 16(72), 706–712. https://doi.org/10.4103/pm.pm_142_20