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    Anticancer Activity of Abietane Diterpenoids from Salvia libanoticum Grown in Lebanon

    Mohamad Ali Hijazi1★, Khadija Hijazi2,3, Kamal Bouhadir4, Zaynab Fatfat5, Maha Aboul‑Ela1, Hala Gali‑Muhtasib1★ Corresponding author

    1. 1Abdalla El‑Lakany Department of Pharmaceutical Sciences, Beirut Arab University.
    2. 2Department of Chemistry, Faculty of Sciences, Beirut Arab University.
    3. 3Department of Natural Sciences, Lebanese American University.
    4. 4Department of Chemistry, American University of Beirut.
    5. 5Department of Biology, American University of Beirut, Departments of.
    6. 6Biology and.
    7. 7Anatomy, Cell Biology and Physiological Sciences, Center for Drug Discovery, American University of Beirut, Beirut, Lebanon.

    CORRESPONDENCE

    Mohamad Ali Hijazi

    Abdalla El‑Lakany Department of Pharmaceutical Sciences, Beirut Arab University.

    m.hijazi@bau.edu.lb

    Received: 29-06-2020; Revised: 25-08-2020; Accepted: 18-12-2020.

    Volume 17, Issue 73 · pp. 127–133 · PUBLISHED 15 April 2021 · DOI: 10.4103/pm.pm_265_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The objectives were to evaluate the potential of abietane diterpenes from the roots of Salvia libanoticum as anticancer agents and explore some essential chemical features. Materials and Methods: Crude extract from the roots of Salvia libanoticum was separated using chromatographic techniques and spectroscopic analysis. The anticancer activities of the isolated compounds along with the crude extract were evaluated against MDA‑MB‑231 breast cancer cells and HCT116 human colon cancer cells using 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay. Results: Eight abietane diterpenes were isolated to be royleanone (1), 6,7‑dehydroroyleanone (2) orthosiphonol (3), horminone (4), 7α‑acetylhorminone (5), taxoquinone (6), 8,9‑epoxy‑7‑oxoroyleanone (7), and 7‑oxoroyleanone (8). All compounds including the extract revealed dose‑dependent inhibitory effects that varied between the two cell lines, indicating cell‑type specificity and suggesting different cell‑compound interactions. Discussion: The most effective compound was found to be 7α‑acetylhorminone, with IC50 of 18 and 44 µM on HCT116 and MDA‑MB‑132 cells, respectively. The results suggested that oxygenated C7 is essential for the cytotoxic activity. Moreover, the carbonyl group at position C7 leads to higher activity than the hydroxyl group. Conclusion: This study reported the potential of abietane diterpinoids as anticancer agents. It also suggested Salvia libanoticum and its diterpinoids as promising remedies in colon and/or breast cancer therapy. Further studies are needed to explore the exact interaction of these compounds with cancer cells at molecular level.

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      Hijazi, M. A., Hijazi, K., Bouhadir, K., Fatfat, Z., Aboul‑Ela, M., & Gali‑Muhtasib, H. (2021). Anticancer Activity of Abietane Diterpenoids from Salvia libanoticum Grown in Lebanon. Pharmacognosy Magazine, 17(73), 127–133. https://doi.org/10.4103/pm.pm_265_20