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    Article

    Targeted Metabolomic Analysis of Seven Short‑Chain Fatty Acids in Feces of Rats with Spleen‑Deficiency Syndrome after Administering Raw and Bran‑Fried Atractylodis Rhizoma by Gas Chromatography‑Mass Spectrometer

    Shanpeng Ma1, Donghua Xue1, Beixue Zhang1, Yujun Jiang1, Qian Cai1★★ Corresponding author

    1. 1Department of Medicine, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.

    CORRESPONDENCE

    Qian Cai

    Department of Medicine, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.

    caiqianmail@sina.com

    Received: 09-05-2020; Revised: 23-06-2020; Accepted: 05-01-2021.

    Volume 17, Issue 73 · pp. 93–100 · PUBLISHED 15 April 2021 · DOI: 10.4103/pm.pm_185_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Aim: The aim of this study was to compare the difference between raw and BFA acting on short‑chain fatty acid (SCFA) metabolism in SDS rats, a metabolic pathway comprising gut flora. Materials and Methods: The model of SDS rats was recognized and then given raw and BFA by gavage. The serum was collected for the determination of motilin (MTL), gastrin (GAS), trypsin (TRY), and amylase (AMS) by enzyme‑linked immunosorbent assay. The feces were collected for the determination of 7 SCFAs under selective ion monitoring mode by gas chromatography‑mass spectrometer. Results: Raw and BFA can upsurge the levels of MTL, GAS, TRY, and AMS in the serum of SDS rats, diminution the levels of acetic acid and propionic acid, and rise the level of hexanoic acid in the feces of SDS rats, and BFA showed noteworthy activity than raw AR. Conclusion: Raw and BFA can improve the acetic acid, propionic acid, and hexanoic acid metabolism in SDS rats, and BFA was more potent than raw AR.

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      Ma, S., Xue, D., Zhang, B., Jiang, Y., & Cai, Q. (2021). Targeted Metabolomic Analysis of Seven Short‑Chain Fatty Acids in Feces of Rats with Spleen‑Deficiency Syndrome after Administering Raw and Bran‑Fried Atractylodis Rhizoma by Gas Chromatography‑Mass Spectrometer. Pharmacognosy Magazine, 17(73), 93–100. https://doi.org/10.4103/pm.pm_185_20