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    Protective Effect of Lycium barbarum on Renal Injury Induced by Acute Pancreatitis in Rats

    Tugba Dogan1, Kadir Batcioglu1★, Elif Kayhan Kustepe2,3, Ayse Burcin Uyumlu1, Yakup Yilmaztekin1★ Corresponding author

    1. 1Department of Biochemistry, Faculty of Pharmacy, İnonu University, Battalgazi, Malatya, Turkey.
    2. 2Department of Histology and Embryology, Faculty of Medicine, İnonu University, Battalgazi, Malatya, Turkey.
    3. 3Department of Basic Medical Sciences, Faculty of Medicine, İnonu University, Battalgazi, Malatya, Turkey.

    CORRESPONDENCE

    Kadir Batcioglu

    Department of Biochemistry, Faculty of Pharmacy, İnonu University, Battalgazi, Malatya, Turkey.

    kadir.batcioglu@inonu.edu.tr

    Received: 05-11-2021; Revised: 25-11-2021; Accepted: 23-12-2021.

    Volume 18, Issue 77 · pp. 152–159 · PUBLISHED 28 March 2022 · DOI: 10.4103/pm.pm_516_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The aim of this study was to investigate the protective efficacy of LB, in kidney damage caused by acute pancreatitis (AP). Materials and Methods: In the study, we used 36 female Wistar albino rats (12 in each group) which were divided into three groups: Control, cerulein (100 μg/kg b. wt. intraperitonally) and Cerulein + LB (6 mg/ml/day gastric gavage) group. Serum lipase, Interleukin (IL)‑1, and IL‑6 levels were measured. Superoxide dismutase, catalase (CAT), glutathione peroxidase enzyme activity assays and 8‑hydroxy deoxyguanosine, malondialdehyde (MDA), and protein levels were measured in kidney tissue samples. In addition, histopathological analysis was performed in kidney tissue samples. Results: According to the findings, in the AP model created with Cerulein, administration of LB plant extract decreased oxidative stress and damage caused by AP in the kidney tissue and partially suppressed the inflammatory reactions in the tissue. Conclusion: According to the findings, in the AP model created with Cerulein, administration of LB extract decreased oxidative stress and in kidney damage caused by AP.

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      Dogan, T., Batcioglu, K., Kustepe, E. K., Uyumlu, A. B., & Yilmaztekin, Y. (2022). Protective Effect of Lycium barbarum on Renal Injury Induced by Acute Pancreatitis in Rats. Pharmacognosy Magazine, 18(77), 152–159. https://doi.org/10.4103/pm.pm_516_21