Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Protective Effect of the Traditional Korean Herbal Prescription, Bojangunbi‑tang, on Non-steroidal Anti‑Inflammatory Drug‑induced Small Bowel Injury

    Minji Cho1★, Jinhyun Bae2, Ji‑Hye Park2, Youngmin Bu2, Beom‑Joon Lee3, Jae‑Woo Park1, Jinsung Kim1, Hye Hyun Yoo4★ Corresponding author

    1. 1Seok‑Jae Ko Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
    2. 2Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
    3. 3Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
    4. 4Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi‑do 15588, Republic of Korea.

    CORRESPONDENCE

    Minji Cho

    Seok‑Jae Ko Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.

    kokokoko119@daum.net

    Received: 20-07-2021; Revised: 19-10-2021; Accepted: 24-12-2021.

    Volume 18, Issue 77 · pp. 183–187 · PUBLISHED 28 March 2022 · DOI: 10.4103/pm.pm_333_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Bojanggunbi‑tang (BGT) is a well‑known combination of ancient Korean herbal medicines and has been widely used for treating gastrointestinal symptoms. Objectives: This study was aimed at investigating whether BGT protects against non-steroidal anti‑inflammatory drug (NSAID)‑induced small intestinal injury (NSI), by using a murine model of indomethacin‑induced NSI. Materials and Methods: NSI was induced in the mice by subcutaneous injections of 15 mg/kg indomethacin. BGT was administered at doses of 50, 150, and 450 mg/kg, while the positive control received sodium alginate. The treatments were orally administered twice, 30 min before and 6 h after the induction of NSI. The body weight, length of small intestine, macroscopic damages, and histological damages were assessed after 24 h of induction. Results: Gross anatomical analysis revealed that BGT inhibited the shortening of the small intestine and reduced the area of ulceration. Histological analysis revealed that BGT lowered the ulceration and inflammation scores. However, there was no difference between the groups with respect to weight loss. Conclusion: BGT ameliorated NSI via its anti‑inflammatory and anti‑ulcerative properties. The current study suggests that BGT could be a therapeutic option for NSI.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Cho, M., Bae, J., Park, J., Bu, Y., Lee, B., Park, J., Kim, J., & Yoo, H. H. (2022). Protective Effect of the Traditional Korean Herbal Prescription, Bojangunbi‑tang, on Non-steroidal Anti‑Inflammatory Drug‑induced Small Bowel Injury. Pharmacognosy Magazine, 18(77), 183–187. https://doi.org/10.4103/pm.pm_333_21