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    Elucidating the Immunomodulatory Effect of Daidzein in Benzo(a)pyrene ‑Induced Lung Cancer Mice Model through Modulation of Proliferating Cell Nuclear Antigen, NF‑κB, CYP1A1, and NRF

    Jianyu Feng1★, Wei Meng1★, Yandong Liu1, Cuiyun Li3, Chunnan Zhang1, Peng Wang1, Hesham S. Almoallim4, Velu Manikandan5, Hui Guan1★★ Corresponding author

    1. 1Departments of Integrated TCM and Western Medicine, Hospital, Harbin, Heilongjiang 150001, China.
    2. 2Emergency and Rehabilitation, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, China.
    3. 3Rehabilitation, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, China.
    4. 4Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh -11545, Saudi Arabia.
    5. 5Division of Biotechnology, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan 54596, South Korea.

    CORRESPONDENCE

    Jianyu Feng

    Departments of Integrated TCM and Western Medicine, Hospital, Harbin, Heilongjiang 150001, China.

    guanhuier2010@sina.com

    Received: 17-07-2021; Revised: 23-09-2021; Accepted: 14-12-2021.

    Volume 18, Issue 77 · pp. 193–200 · PUBLISHED 28 March 2022 · DOI: 10.4103/pm.pm_325_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: In this study, we aimed to understand the immunomodulatory activity of DAZ in the mice model with benzo(a)pyrene (B(a)P)‑induced lung carcinoma. Materials and Methods: The mice were divided into five groups: Group I served was the control group; Group II animals were challenged with B(a)P; Group III animals were treated with DAZ before challenge with B(a) P; Group IV animals were treated with DAZ after challenging the animals with B(a)P; and Group V animals were treated with DAZ alone till the end of the experimental period. Tumor incidence was calculated, and the following parameters were analyzed: Body weight, lung weight, total number of tumors, percentage of inhibition, immunoglobulin (Ig) levels (immunoglobulin G, immunoglobulin A, and immunoglobulin M), key marker enzymes, and proinflammatory cytokines in both treated and normal mice. The lung tissues were analyzed through the histopathological analysis. Results: According to our results, all the markers that favor the growth of cancer were increased in the lung cancer group. After the administration of DAZ, all the markers returned to their original levels. Conclusion: In conclusion, DAZ protected the cells against the B(a)P‑induced inflammatory responses in lung cancer.

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      Feng, J., Meng, W., Liu, Y., Li, C., Zhang, C., Wang, P., Almoallim, H. S., Manikandan, V., & Guan, H. (2022). Elucidating the Immunomodulatory Effect of Daidzein in Benzo(a)pyrene ‑Induced Lung Cancer Mice Model through Modulation of Proliferating Cell Nuclear Antigen, NF‑κB, CYP1A1, and NRF. Pharmacognosy Magazine, 18(77), 193–200. https://doi.org/10.4103/pm.pm_325_21