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    Article

    Enhanced Synergistic Antitumor Efficacy with Topotecan (Camptothecin Derivative) and Curcumin Analogs Coadministration in Novel Proniosomal Formulations

    Afzal Haq Asif1★, Predeepkumar Narayanappa Shiroorkar2, Purna Singh2, Pottathil Shinu3, Nagaraja Sreeharsha4,5, Md. Khalid Anwer6★ Corresponding author

    1. 1Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa 31982, Saudi Arabia.
    2. 2Department of Biomedical Sciences, College of Medicine, King Faisal University, Al‑Ahsa 31982, Saudi Arabia.
    3. 3Department of Biomedical Sciences and Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa 31982, Saudi Arabia.
    4. 4Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bengaluru, Karnataka, India.
    5. 5Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al‑Alkharj, Saudi Arabia.

    CORRESPONDENCE

    Afzal Haq Asif

    Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa 31982, Saudi Arabia.

    ahasif@kfu.edu.sa

    Received: 21-12-2021; Revised: 05-01-2022; Accepted: 12-01-2022.

    Volume 18, Issue 77 · pp. 233–241 · PUBLISHED 7 March 2022 · DOI: 10.4103/pm.pm_588_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: In the modern era of therapeutics, the proniosomal system has been identified as the most intriguing one among various novel systems, thus considerably enhancing the bioavailability of low‑soluble drugs. The current study aimed to study the enhancement of therapeutic efficacy of topotecan (TPT) with curcumin (CUR) coadministration. Materials and Methods: We optimized the preparation of niosomes, concerning concentrations of lecithin, span 60, and cholesterol. Seventeen trials were proposed by the selected design. All these batches were initially evaluated only for entrapment efficacy (EE), vesicle size (VS), and percentage of TPT release by the end of 12 h. Analysis of variance and generated regression equations were assisted to study the significant variables and magnitude of impact. Results: The desirability of 0.893 was achieved with the optimum concentrations of selected independent variables in attaining the highest EE (90.393%), minimum VS (386.264 nm), and percentage of TPT release (98.614% at 12 h). TPT and CUR release from the optimized formulation were found to be anomalous or non‑Fickian diffusion, as evident from the n value of Peppas model. The cytotoxic studies demonstrated that TPT and CUR in liposomal and free forms were found to be less cytotoxic on MCF‑7 model cells. All these findings indicate that the coadministration of CUR with TPT proniosomes can be a promising strategy to enhance the antitumor treatment.

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      Asif, A. H., Shiroorkar, P. N., Singh, P., Shinu, P., Sreeharsha, N., & Anwer, M. K. (2022). Enhanced Synergistic Antitumor Efficacy with Topotecan (Camptothecin Derivative) and Curcumin Analogs Coadministration in Novel Proniosomal Formulations. Pharmacognosy Magazine, 18(77), 233–241. https://doi.org/10.4103/pm.pm_588_21